Results 51 to 60 of about 71,827 (219)

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Ultrasonic regeneration of activated carbon with the addition of gas flushing

Desalination and Water Treatment
In this study, we investigated the effects of four operating parameters; frequency, power, gas impulse intensity, and regeneration time, on the regeneration of activated carbon.
Zhiwei Wang, Bingjie Zhou, Zhendong Liu, Lu Li, Kemei Zhou, Tian Tian, Binbin Wu, Wanting Feng, Yuanxiang Shan, Hongqin Xue, Zheng Wang   +10 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

A dual-process psychological model of impulse buying in digital commerce: evidence from livestream and marketplace contexts

Frontiers in Psychology
The rapid rise of livestream social commerce has reshaped online shopping by combining algorithmic personalization, entertainment, and real-time persuasion.
Qiu Xilai, Tayyeba Bashir, Ammara Naseem, Rana Faizan Gul, Burhan Sadiq   +4 more
doaj   +1 more source

Experimental and numerical investigation of design optimization of a partial admitted supersonic turbine

Propulsion and Power Research, 2013
To obtain a high specific work output, the large pressure ratios across the turbine are required. This can be achieved using a supersonic turbine. When the fluid mass flow is low, the impulse kind of one or two stages supersonic turbine is employed.
Reza Aghaei tog, Abolghasem M. Tousi
doaj   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Blast characteristics of center-initiated cylindrical charge in high-altitude environments

AIP Advances
The effects of different high-altitudes on the blast parameters—including peak overpressure and specific impulse—produced by a center-initiated cylindrical charge (CC) were simulated using the AUTODYN software and analyzed through dimensional analysis ...
Rui Li, Rui Sun, Ming-hang Hu, Ya-jing Chen, Quan Wang, Dong-Dong Zhang, Xue-jiao Li, Xiao-rong Cui   +7 more
doaj   +1 more source

Perceived Impacts and Predictors of Cannabis Products Used by Patients with Rheumatologic Conditions in Alberta, Canada: A Multivariable Analysis of Cross‐Sectional Survey Data

Arthritis Care &Research, EarlyView.
Objective This study aimed to characterize cannabis product choices (cannabinoid content and formulation) among patients with rheumatologic conditions and their associations with patient factors, patient‐reported perceived side effects, and positive impacts.
Susan Zhang, Samuel A.J. Lowe, Frank Sun, Allyson Jones, Tarek Turk, Joanne Olson, Pauline Paul, Shelby Yamamoto, Linda Kolewaski, Elaine Yacyshyn, Cheryl A. Sadowski   +10 more
wiley   +1 more source

Associations of Lifestyle‐Related Factors and Psoriatic Arthritis Disease Activity: The Dutch South West Psoriatic Arthritis Study

Arthritis Care &Research, EarlyView.
Objective This study aims to investigate lifestyle‐related factors in patients with psoriatic arthritis (PsA) and their association with disease activity measurements. Methods This multicenter cohort included 938 patients who were newly diagnosed with PsA between 2013 and 2023.
Batoul Hojeij, Ilja Tchetverikov, Marc R. Kok, Marijn Vis, Yvonne Goekoop‐Ruiterman, Jessica Bijsterbosch, Paul Baudoin, Reinhard Bos, Jos H. van der Kaap, Petra Kok, Lindy‐Anne Korswagen, Jolanda J. Luime   +11 more
wiley   +1 more source

Numerical Simulation of the Behavior of Impulse Gas Seals

Tribology Online
This paper presents a numerical simulation of an impulse gas seal. Impulse gas seals are mechanical seals equipped with feeding grooves on the stator and chambers on the rotor.
Noël Brunetière, Andriy Zahorulko, Jean Bouyer   +2 more
doaj   +1 more source