Results 41 to 50 of about 23,913,885 (292)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Effect of Enhancement Material on the Performance of Ground Electrodes Under Impulse Conditions

IEEE Access
Among the factors that affect the soil resistivity is the chemical content in soil, where the ionic conduction is expectedly increased and the soil resistivity is reduced.
Usman Muhammad, Nurul Nadia Ahmad, Normiza Mohamad Nor, Fazlul Aman   +3 more
doaj   +1 more source

Hardware and power management for high power impulse magnetron sputtering

, 2019
The work that led to the development of the HiPIMS technique was initiated at the Moscow Engineering and Physics Institute (MEPhI) in the late 1960s, where high power pulses were applied to diode sputter sources.
Zdeněk Hubička, Gudmundsson, Jon Tomas,, Jon Tomas Gudmundsson, Lundin, D., Hubička, Z., Daniel Lundin, Petter Larsson, Larsson, P.   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Impulse ageing of polymeric materials

, 2011
Impulse over-voltage is a common phenomenon in electric power systems. A switching impulse is created by a switching surge or local fault while a lightning impulse is due to direct lightning strike to high voltage plant such as an overhead line.
Dao, Ngoc Long
core   +1 more source

[2+2] and [2+1] cycloaddition of myrcene for synthesis of highly strained bio-fuels with high density and high impulse

Energetic Materials Frontiers
Developing bio-fuels provides a sustainable strategy to reduce the dependence on finite fossil fuels. But biomass-based fuel molecules usually lack strained structure, resulting in undesirable density and impulse for aerospace applications.
Jin-xiu Hu, Min-hua Ai, Xian-long Liu, Xiao-lei Guo, Cheng-xiang Shi, Kang Xue, Xiang-wen Zhang, Li Wang, Ji-Jun Zou, Lun Pan   +9 more
doaj   +1 more source

"Effects of electrohydroimpulse discharges on the crushing of the natural mineral quartz "

Eurasian Physical Technical Journal, 2019
Electro-hydro-impulse (high-current discharge in water) also belongs to the technologies using strong impulse currents. With a powerful pulsed electric discharge between the electrodes placed in the liquid, an electro-hydraulic effect occurs.
G.A. Bulkairova, M. Stoev, A.K. Khassenov, D.Zh. Karabekova, Zh.G. Nurgaliyeva, M.S. Kipshakov   +5 more
doaj   +1 more source

MIRaGe: Multichannel Database Of Room Impulse Responses Measured On High-Resolution Cube-Shaped Grid In Multiple Acoustic Conditions

CoRR, 2019
We introduce a database of multi-channel recordings performed in an acoustic lab with adjustable reverberation time. The recordings provide information about room impulse responses (RIR) for various positions of a loudspeaker. In particular, the main positions correspond to 4104 vertices of a cube-shaped dense grid within a 46x36x32 cm volume.
Jaroslav Cmejla, Tomás Kounovský, Sharon Gannot, Zbynek Koldovský, Pinchas Tandeitnik   +4 more
openaire   +2 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Impulse Characteristics of Various Soil-Enhancement Material Mixtures

Applied Sciences
Many studies have demonstrated that a reduction in ground impedance value occurs under high-impulse current magnitudes, due to the ionisation process in soil.
Fazlul Aman, Usman Muhammad, Normiza Mohamad Nor, Haziah Abdul Hamid   +3 more
doaj   +1 more source