Results 61 to 70 of about 457,205 (201)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Reconfiguration strategy of shipboard power system adapting to impulse load access

Zhongguo Jianchuan Yanjiu
ObjectiveShipboard power systems (SPS) are vulnerable to attacks, often resulting in a degraded or partially damaged state. In this state, the system exhibits low inertia, and the connection of critical loads, mainly high-power impulse loads, may cause ...
Ang XU, Xingbao JU, Fanrong WEI
doaj   +1 more source

A new perspective on the irregular satellites of Saturn - II Dynamical and physical origin

, 2009
The origin of the irregular satellites of the giant planets has been long debated since their discovery. Their dynamical features argue against an in-situ formation suggesting they are captured bodies, yet there is no global consensus on the physical ...
Benz, Buratti, Colombo, D. Turrini, Delsanti, F. Marzari, F. Tosi, Giese, Gomes, Grav, Grav, Jewitt, Morbidelli, Nesvorny, Pierazzo, Porco, Schmidt, Sheppard, Tsiganis, Turrini, Zappalá, Zappalá   +21 more
core   +1 more source

Impulse-driven surface breakdown data : a Weibull statistical analysis [PDF]

, 2012
Surface breakdown of oil-immersed solids chosen to insulate high-voltage, pulsed-power systems is a problem that can lead to catastrophic failure. Statistical analysis of the breakdown voltages, or times, associated with such liquid-solid interfaces can ...
Given, M, Lehr, Jane, MacGregor, Scott, Sinclair, M.A., Thomas, K.J., Timoshkin, Igor, Wang, Tao, Wilson, Mark   +7 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dynamic response of polymethacrylimide foam sandwich structures with different core layers under water impact loading

Defence Technology
Polymethacrylimide (PMI) foam has the highest specific stiffness and strength among polymer foams, with excellent radar-absorbing capabilities, which provide it with broad prospects in underwater applications.
Peilin Zhu, Jili Rong, Shenglong Wang, Zichao Chen, Zifan Jiang   +4 more
doaj   +1 more source

EXPERIMENTAL RESEARCH OF CONTROLLING HIGH VOLTAGE TRANSFORMER WINDING CONDITION BASED ON SWITCHING IMPULSES

Известия Томского политехнического университета: Инжиниринг георесурсов, 2020
The importance of the research is driven by the exceptional importance of stable work of electrical equipment complex which is used at production, transportation and processing of geo-resources. Effectiveness and reliability of such geological production is strongly depends on high voltage transformer condition.
Valeriy A. Lavrinovich, Alexey V. Lavrinovich, Alexey V. Mytnikov   +2 more
openaire   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Atmospheric Conditions Correction for Positive Switching Breakdown Voltage of 1-m Rod-Plate Gap

IEEE Access
As converter stations are increasingly constructed at high altitudes, how to reasonably select the minimum air spacing of converter station substation equipment has become an important issue for DC power transmission at high altitudes.
Yong Sun, Zhijin Zhang, Hailin Shi, Jinzhuang Lv, Xiaoxing Wei, Yanjie Cui   +5 more
doaj   +1 more source

Lightning impulse tests on air-breakdown level in point-plane electrode configuration [PDF]

, 2014
In the past several decades, extensive amount of research work has been done to understand the fundamental characteristics of the electrical breakdown.
Che Mok @ Adnan, Mohd Dasri
core