Results 91 to 100 of about 559,532 (297)

Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. [PDF]

PLoS ONE, 2012
BackgroundExtracellular high mobility group box 1 (HMGB1) protein can operate in a synergistic fashion with different signal molecules promoting an increase of cell Ca(2+) influx.
Marco Pedrazzi, Monica Averna, Bianca Sparatore, Mauro Patrone, Franca Salamino, Manuela Marcoli, Guido Maura, Chiara Cervetto, Daniela Frattaroli, Sandro Pontremoli, Edon Melloni   +10 more
doaj   +1 more source

B Cell Activation in Insulin Resistance and Obesity [PDF]

, 2011
Our group has demonstrated that inflammatory diseases such as type 2 diabetes (DM), inflammatory bowel disease (IBD), and periodontal disease (PD) are associated with altered B cell function that may contribute to disease pathogenesis. B cells were found
Apovian, Caroline, Ganley-Leal, Lisa, Gokce, Noyan, Liang, YanMei, McDonnell, Marie, Mehta, Ankeeta, Zhang, Jeanette   +6 more
core   +1 more source

The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [PDF]

, 2014
BACKGROUND: The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic ...
Bobek, Dubravka, Grčević, Danka, Jelušić, Marija, Kovačić, Nataša, Lukić, Ivan Krešimir   +4 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Specific detection of high mobility group box 1 degradation product with a novel ELISA

Molecular Medicine, 2021
Background During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inflammation and remote organ failure.
Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori, Ikuro Maruyama   +5 more
doaj   +1 more source

High mobility group box 1 and refeeding-resistance in anorexia nervosa [PDF]

Molecular Psychiatry, 2007
Anorexia nervosa (AN) is a serious disorder affecting adolescents and young adults, and decreases quality of life over long period.1 Successful weight restoration is an important prognostic factor for disease outcome;1 however, the underlying mechanism of refeeding-resistance (RR), a core psychopathology relevant to 'ambivalent' eating behaviors ...
D, Yasuhara, T, Hashiguchi, K, Kawahara, T, Nakahara, T, Harada, H, Taguchi, S, Yamada, I, Maruyama, A, Inui   +8 more
openaire   +2 more sources

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein, Maximilian Mönch, Meret Herdick, Frauke Stascheit, Sarah Hoffmann, Hannah Preßler, Philipp Mergenthaler, Carla Dusemund, Paolo Doksani, Haoqi Sun, Pushpa Narayanaswami, Andreas Meisel, Lea Gerischer, Sophie Lehnerer   +13 more
wiley   +1 more source

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Cellular Physiology and Biochemistry, 2018
High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to
Han Wu, Ran Li, Li-Gang Pei, Zhong-Hai Wei, Li-Na Kang, Lian Wang, Jun Xie, Biao Xu   +7 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies

Frontiers in Cell and Developmental Biology, 2020
IntroductionHigh Mobility Group Box Protein 1 (HMGB1) is a DNA-binding protein that exerts inflammatory or pro-repair effects upon translocation from the nucleus.
Jessica Day, Jessica Day, Jessica Day, Sophia Otto, Sophia Otto, Kathy Cash, Preethi Eldi, Preethi Eldi, Pravin Hissaria, Pravin Hissaria, Susanna Proudman, Susanna Proudman, Vidya Limaye, Vidya Limaye, John D. Hayball, John D. Hayball, John D. Hayball   +16 more
doaj   +1 more source