Results 71 to 80 of about 559,532 (297)

Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis [PDF]

International Journal of Ophthalmology, 2019
AIM: To investigate the inflammatory amplification effect of high-mobility group box 1 (HMGB1) in Aspergillus fumigatus (A. fumigatus) keratitis and the relationship between lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) and HMGB1 in ...
Jia-Qian Jiang, Cui Li, Cong-Xian Cui, Yu-Na Ma, Gui-Qiu Zhao, Xu-Dong Peng, Qiang Xu, Qian Wang, Guo-Qiang Zhu, Chen-Yu Li   +9 more
doaj   +1 more source

Establishment of in Vitro Binding Assay of High Mobility Group Box-1 and S100A12 to Receptor for Advanced Glycation Endproducts: Heparin's Effect on Binding [PDF]

, 2009
Interaction between the receptor for advanced glycation end products (RAGE) and its ligands has been implicated in the pathogenesis of various inflammatory disorders.
Izushi, Yasuhisa, Liu, Keyue, Liu, Rui, Mori, Shuji, Nishibori, Masahiro, Peng, Bo, Takahashi, Hideo K., Wake, Hidenori, Zhang, Jiyong   +8 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Toxoplasma gondii Infection Induces High Mobility Group Box 1 Released from Mouse Macrophages

Frontiers in Microbiology, 2017
High mobility group box 1 (HMGB1) is abundantly expressed in intracellular engaged DNA binding ability. However, more importantly, it is a weapon against infection through proinflammatory response and immune regulation while released to extracellular ...
Qun Liu, Hui Wang, Hui Wang, Muzi Li, Jing Liu, Jianhai Xu, Qian Han   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1 [PDF]

, 2013
High mobility group box-1 (HMGB1) is associated with the pathogenesis of inflammatory diseases. A previous study reported that intravenous injection of anti-HMGB1 monoclonal antibody significantly attenuated brain edema in a rat model of stroke, possibly
D Lo Coco, E Abraham, EA Romero-Sandoval, Fang Fang Zhang, H Wang, H Yang, Hiromi Abe, I Hide, J Zhang, JA Coull, JB Kim, JH Youn, JR Klune, K Liu, Kazue Hisaoka-Nakashima, Keyue Liu, M Shibasaki, M Tsuda, M Tsuda, M Tsuda, M Xia, Masabumi Minami, Masahiro Nishibori, MK Jha, MT Lotze, N Taniguchi, Norimitsu Morioka, P Feldman, P Kanellakis, PC Ren, RK Wang, S Beggs, S Echeverry, T Nakagawa, T Trang, U Andersson, U Andersson, W Sheng, W Tong, Y Li, Y Okuma, Yoki Nakamura, Yoshihiro Nakata, Z Seltzer   +43 more
core   +3 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes

Hepatology Communications, 2021
High‐mobility group box 1 (HMGB1) is a nucleoprotein with proinflammatory functions following cellular release during tissue damage. Moreover, antibody‐mediated HMGB1 neutralization alleviates lipopolysaccharide (LPS)‐induced shock, suggesting a role for
Annika Volmari, Katharina Foelsch, Elisabeth Zierz, Karsten Yan, Minyue Qi, Karlotta Bartels, Stephanie Kondratowicz, Marius Boettcher, Daniel Reimers, Masahiro Nishibori, Keyue Liu, Robert F. Schwabe, Ansgar W. Lohse, Samuel Huber, Hans‐Willi Mittruecker, Peter Huebener   +15 more
doaj   +1 more source

A possible role of HMGB1 in DNA demethylation in CD4+ T Cells from patients with systemic lupus erythematosus [PDF]

, 2013
The aberrant activity of CD4(+) T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes.
Chan, DTM, Huang, C, Li, Y, Liang, G, Lu, Q, Xiao, R, Yung, SSY, Zhao, M   +7 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source