Results 61 to 70 of about 559,532 (297)

The Role of High Mobility Group Box-1 in Epileptogenesis.

Acta medica Okayama, 2019
High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). HMGB1 has been reported to play an important role during epileptogenesis although the mechanisms of its actions are still not clear.
Fu, Li, Nishibori, Masahiro
openaire   +3 more sources

High-Mobility Group Box 1 in Dry Eye Inflammation

Investigative Opthalmology & Visual Science, 2018
To determine high-mobility group box 1 (HMGB1) expression during experimental dry eye (EDE) and dry eye-like culture conditions and elucidate its role in corneal dry eye-related inflammation.EDE was induced in 8- to 12-week-old C57BL/6 mice. Corneal tissue sections and lysates from EDE and untreated mice were evaluated for HMGB1 expression by ...
Lema, Carolina, Reins, Rose Y., Redfern, Rachel L.   +2 more
openaire   +2 more sources

High-mobility group box 1 is a novel deacetylation target of Sirtuin1 [PDF]

Kidney International, 2015
High-mobility group box 1 (HMGB1) undergoes acetylation, nuclear-to-cytoplasmic translocation, and release from stressed kidneys, unleashing a signaling cascade of events leading to systemic inflammation. Here, we tested whether the deacetylase activity of Sirtuin1 (SIRT1) participates in regulating nuclear retention of HMGB1 to ultimately modulate ...
Rabadi, May M., Xavier, Sandhya, Vasko, Radovan, Kaur, Kavneet, Goligorksy, Michael S., Ratliff, Brian B.   +5 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

High-Mobility Group Box 1-Induced Complement Activation Causes Sterile Inflammation

Frontiers in Immunology, 2018
High-mobility group box 1 (HMGB1), a well-known danger-associated molecular pattern molecule, acts as a pro-inflammatory molecule when secreted by activated immune cells or released after necrotic cell damage.
Sook Young Kim, Myoungsun Son, Sang Eun Lee, In Ho Park, In Ho Park, Man Sup Kwak, Myeonggil Han, Hyun Sook Lee, Eun Sook Kim, Jae-Young Kim, Jong Eun Lee, Ji Eun Choi, Betty Diamond, Jeon-Soo Shin, Jeon-Soo Shin, Jeon-Soo Shin   +15 more
doaj   +1 more source

High mobility group box 1 and kidney diseases (Review)

International Journal of Molecular Medicine, 2013
High mobility group box 1 (HMGB1), a non-histone DNA-binding protein, regulates nucleosome function and transcription in the nuclei of all metazoans and plants. However, extracellular HMGB1, which is actively or passively released under different conditions, can act as a key inflammatory mediator through MyD88/mitogen-activated protein kinase signaling
Ping, Zhu, Li, Xie, Hua-Sheng, Ding, Quan, Gong, Jian, Yang, Lin, Yang   +5 more
openaire   +3 more sources

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review

International Archives of Otorhinolaryngology, 2016
Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced ...
Austin Nguyen, Sheila Bhavsar, Erinn Riley, Gabriel Caponetti, Devendra Agrawal   +4 more
doaj   +1 more source