Results 71 to 80 of about 559,331 (298)

Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review

International Archives of Otorhinolaryngology, 2016
Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced ...
Austin Nguyen, Sheila Bhavsar, Erinn Riley, Gabriel Caponetti, Devendra Agrawal   +4 more
doaj   +1 more source

Neuropathic Pain in Rats with a Partial Sciatic Nerve Ligation Is Alleviated by Intravenous Injection of Monoclonal Antibody to High Mobility Group Box-1 [PDF]

, 2013
High mobility group box-1 (HMGB1) is associated with the pathogenesis of inflammatory diseases. A previous study reported that intravenous injection of anti-HMGB1 monoclonal antibody significantly attenuated brain edema in a rat model of stroke, possibly
D Lo Coco, E Abraham, EA Romero-Sandoval, Fang Fang Zhang, H Wang, H Yang, Hiromi Abe, I Hide, J Zhang, JA Coull, JB Kim, JH Youn, JR Klune, K Liu, Kazue Hisaoka-Nakashima, Keyue Liu, M Shibasaki, M Tsuda, M Tsuda, M Tsuda, M Xia, Masabumi Minami, Masahiro Nishibori, MK Jha, MT Lotze, N Taniguchi, Norimitsu Morioka, P Feldman, P Kanellakis, PC Ren, RK Wang, S Beggs, S Echeverry, T Nakagawa, T Trang, U Andersson, U Andersson, W Sheng, W Tong, Y Li, Y Okuma, Yoki Nakamura, Yoshihiro Nakata, Z Seltzer   +43 more
core   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Establishment of in Vitro Binding Assay of High Mobility Group Box-1 and S100A12 to Receptor for Advanced Glycation Endproducts: Heparin's Effect on Binding [PDF]

, 2009
Interaction between the receptor for advanced glycation end products (RAGE) and its ligands has been implicated in the pathogenesis of various inflammatory disorders.
Izushi, Yasuhisa, Liu, Keyue, Liu, Rui, Mori, Shuji, Nishibori, Masahiro, Peng, Bo, Takahashi, Hideo K., Wake, Hidenori, Zhang, Jiyong   +8 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Leukocyte‐Derived High‐Mobility Group Box 1 Governs Hepatic Immune Responses to Listeria monocytogenes

Hepatology Communications, 2021
High‐mobility group box 1 (HMGB1) is a nucleoprotein with proinflammatory functions following cellular release during tissue damage. Moreover, antibody‐mediated HMGB1 neutralization alleviates lipopolysaccharide (LPS)‐induced shock, suggesting a role for
Annika Volmari, Katharina Foelsch, Elisabeth Zierz, Karsten Yan, Minyue Qi, Karlotta Bartels, Stephanie Kondratowicz, Marius Boettcher, Daniel Reimers, Masahiro Nishibori, Keyue Liu, Robert F. Schwabe, Ansgar W. Lohse, Samuel Huber, Hans‐Willi Mittruecker, Peter Huebener   +15 more
doaj   +1 more source

A possible role of HMGB1 in DNA demethylation in CD4+ T Cells from patients with systemic lupus erythematosus [PDF]

, 2013
The aberrant activity of CD4(+) T cells in patients with systemic lupus erythematosus (SLE) is associated with DNA hypomethylation of the regulatory regions in CD11a and CD70 genes.
Chan, DTM, Huang, C, Li, Y, Liang, G, Lu, Q, Xiao, R, Yung, SSY, Zhao, M   +7 more
core   +3 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

High mobility group box 1/toll-like receptor 4/myeloid differentiation factor 88 signaling promotes progression of gastric cancer

Tumor Biology, 2017
High mobility group box 1 and toll-like receptor 4/myeloid differentiation factor 88 signaling pathway have been indicated to have oncogenic effects in many cancers.
Yanqiu Yue, Tao Zhou, Yanjing Gao, Zongli Zhang, Li Li, Lin Liu, Wenna Shi, Lihui Su, Baoquan Cheng   +8 more
doaj   +1 more source

Peripheral HMGB1-induced hyperalgesia in mice: Redox state-dependent distinct roles of RAGE and TLR4

Journal of Pharmacological Sciences, 2016
Nuclear HMGB1 that contains 3 cysteine residues is acetylated and secreted to the extracellular space, promoting inflammation via multiple molecules such as RAGE and TLR4.
Daichi Yamasoba, Maho Tsubota, Risa Domoto, Fumiko Sekiguchi, Hiroyuki Nishikawa, Keyue Liu, Masahiro Nishibori, Hiroyasu Ishikura, Tetsushi Yamamoto, Atsushi Taga, Atsufumi Kawabata   +10 more
doaj   +1 more source