Results 41 to 50 of about 693,447 (358)

Chemical characterization of the photodegradation products of midazolam complexes with randomly methylated-β-cyclodextrin by HPLC and LC-MS/MS [PDF]

Journal of the Serbian Chemical Society, 2016
Midazolam, a potent anxiolytic drug with sedative properties, is susceptible to degradation by both light and hydrolysis in aqueous solution. When formulated as an intranasal product it was found to be effective in achieving seizure control in ...
Agatonovic-Kustrin Snezana, Lebete Mosimotsana, Brown Michael E., Morton David W., Glass Beverley D.   +4 more
doaj   +1 more source

Ultra Performance Liquid Chromatography (UPLC) - A Review

International Journal For Multidisciplinary Research, 2023
Ultra performance liquid chromatography is a modern technique which gives a new direction for liquid chromatography. ultra performance liquid chromatography is a technique that improves in three key areas: "speed, resolution, and sensitivity.".
Nimbalkar Tanuja Sanjay, Varnekar Dhanashri Sanjay   +1 more
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Desenvolvimento e validação de método analítico para quantificação do fármaco bevacizumabe por cromatografia a líquido de alta eficiência

Química Nova, 2012
In this study, an analytical method was developed and validated for quantitation of the drug bevacizumab (Avastin®) by high performance liquid chromatography (HPLC). The HPLC column was a BioSuite 250® HR SEC, 300 x 7.8 mm x 5 µm (Waters, USA).
Elionai Cassiana de Lima Gomes, Armando da Silva Cunha Júnior, Maria Irene Yoshida, Rodrigo Jorge   +3 more
doaj   +1 more source

Multidimensional High-Performance Liquid Chromatography [PDF]

, 2011
This chapter explores alternative methods for obtaining chemical fingerprints, that being, multidimensional high-performance liquid chromatography (MDHPLC). HPLC is the most commonly used analytical separation technique for the determination of components in complex mixtures as it offers high sensitivity and can be highly selective.
Milroy, Coleen S. (R13959), Stevenson, Paul G. (S24783), Mnatsakanyan, Mariam (R16716), Shalliker, Ross A. (R8557)   +3 more
openaire   +2 more sources

A rapid and sensitive method for determination of carotenoids in plant tissues by high performance liquid chromatography

Plant Methods, 2015
The dietary carotenoids serve as precursor for vitamin A and prevent several chronic-degenerative diseases. The carotenoid profiling is necessary to understand their importance on human health.
Prateek Gupta, Y. Sreelakshmi, Rameshwar Sharma   +2 more
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Development and validation of a dissolution test for diltiazem hydrochloride in immediate release capsules

Química Nova, 2011
This work describes the development and validation of a dissolution test for 60 mg of diltiazem hydrochloride in immediate release capsules. The best dissolution in vitro profile was achieved using potassium phosphate buffer at pH 6.8 as the dissolution ...
Taciane Ferreira Mendonça, Eliézer Giannini de Barros, Gislaine Ribeiro Pereira, Magali Benjamim de Araújo, Rudy Bonfilio   +4 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

MYCOBACTERIUM COMPLEX IDENTIFICATION BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Journal of Research in Medical Sciences, 2001
Introduction: There are different ways for identification of Mycobacteria. One of the most sensitive method is HPLC of phenacyl esters of mycolic acids of Mycobacteria for rapid identification of them after their primary cultures.
S.A HAWAII, T NASERPUR-FARIVAR, G.A NADERI, H TAMIZI FAR   +3 more
doaj