Results 121 to 130 of about 380,525 (307)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Simulating Speed in Language: Contributions from vision, audition and action
, 2015 Embodied theories propose that understanding meaning in language requires the mental simulation of entities being referred to. These mental simulations would make use of the same modality-specific systems involved in perceiving and acting upon such ...
Speed, LJ
core
High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis. [PDF]
Proc Natl Acad Sci U S A, 2023 Zhang P, Rumschitzki D, Edwards RH.
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
High-throughput single-cell imaging by multi-modal FACED microscopy
, 2019 We demonstrate a high-throughput multimodal imaging flow cytometry platform based on a recently developed all-optical laser scanning technique dubbed free-space angular chirped enhanced delay (FACED).
Wong, KKY +4 more
core
Experimental dataset of U-folded falling chain under various openings with high-speed imaging. [PDF]
Data Brief, 2023 Markou AA +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Stereoscopic high dynamic range imaging [PDF]
Two modern technologies show promise to dramatically increase immersion in virtual environments. Stereoscopic imaging captures two images representing the views of both eyes and allows for better depth perception.
Selmanovic, Elmedin
core
Range imager performance comparison in homodyne and heterodyne operating modes
, 2009 Range imaging cameras measure depth simultaneously for every pixel in a given field of view. In most implementations the basic operating principles are the same.
Dorrington, Adrian A. +3 more
core +1 more source