Results 121 to 130 of about 24,558,722 (248)

An Extendable High Step‐Up Interleaved DC–DC Converter Utilizing a Switched Capacitor Cell

IET Power Electronics
A DC–DC interleaved converter with a coupled inductor is proposed in this study. This converter is capable of generating high voltage through the use of switched capacitors and additional components.
Darioush Alizadeh, Ebrahim Babaei, S. M. J. Mousavi   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A new soft‐switching high step‐up DC–DC converter with low voltage stress

Energy Science & Engineering
This paper proposes a new high step‐up DC–DC converter with zero input current ripple for renewable energy sources applications, such as fuel cells. In this topology, a coupled inductor and a multiplier cell are used to achieve high voltage gains.
Preeti Sharma, Sara Hasanpour, Rajneesh Kumar   +2 more
doaj   +1 more source

High Step-Up DC-DC Converter for Distributed Generation System

, 2013
: This study proposes a method which consists of High step up DC-DC converter with a coupled inductor for distributed generation system. Theoretically the conventional boost converter provides high step up voltage gain but in practical it is limited by ...

core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Analysis and Implementation of an Interleaved High Step‐Up Converter With Zero‐Voltage‐Switching

IET Power Electronics
In this paper, a high step‐up DC‐DC converter is presented. The input current ripple is reduced by adding the interleaving technique on the input side.
Marzieh Mohammadi Jouzdani, Omid Haghparast Naeini, Mahdi Shaneh, Tohid Nouri   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

High step up DC–DC converter with low conduction losses and reduced switching losses

IET Renewable Power Generation
This article presents a novel high step up converter based on the active switch inductor (ASL) technique for renewable energy source applications. The coupled inductor technique provides an opportunity to increase the gain.
Zahra Akhlaghi, Amirhossein Karimi, Ehsan Adib   +2 more
doaj   +1 more source