Results 91 to 100 of about 1,454,923 (313)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Determining the effect of strain rate on the fracture of sheet steel [PDF]

open access: yes
A key challenge for the automotive industry is to reduce vehicle mass without compromising on crash safety. To achieve this, it is necessary to model local failure in a material rather than design to the overly conservative criteria of total elongation
Beaumont, Richard Adrian
core  

High strain-rate behavior and deformation mechanism of a multi-layer composite textured AZ31B Mg alloy plate

open access: yes, 2018
There are currently very few studies on the high strain-rate properties of Mg alloys with multi-layer composite textures under dynamic loading. In present study, a multi-layer composite textured AZ31B Mg alloy plate was fabricated using the asymmetric ...
Zhang WG   +8 more
core   +1 more source

Detonation Induced Strain in Tubes [PDF]

open access: yes, 2010
When a detonation wave propagates through a piping system, it acts as a traveling pressure load to the pipe wall. The detonation wave must be followed by an expansion wave in order to bring the combustion products to zero velocity at the ignition end ...
Karnesky, James Alan
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Mechanical Behavior of a High-Strength Austenitic Steel Under Dynamical Biaxial Loading

open access: yes
107115Uniaxial and biaxial experiments were carried out on the high strength austenitic steel X 2 CrNiMnMoNNb 21 16 5 3 at room temperature in the strain rate range from 10-5 up to 102 s-1.
Staskewitsch, Ewald S., Stiebler, K.
core   +1 more source

Dynamic recrystallization of pure zinc during high strain-rate compression at ambient temperature

open access: yes, 2020
Due to limited slip systems, forming of Zn-based alloys is typically conducted at elevated temperatures which consumes energy and may degrade mechanical properties.
Kent, D   +5 more
core   +1 more source

Strain rate and temperature dependence of Omori law scaling constants of AE data: Implications for earthquake foreshock-aftershock sequences [PDF]

open access: yes, 2004
Little is known about the temperature and strain rate dependence of acoustic emission AE activity (AE). Hence, we carried out a preliminary series of flow-through triaxial compression tests on porous sandstones at different temperatures and strain rates.
Ira O. Ojala   +3 more
core   +1 more source

High-Strain-Rate Behavior of 3D-Printed CuCrZr

open access: yes, 2023
CuCrZr alloys achieve high mechanical properties by thermal (e.g., supersaturated temper and aging), mechanical (e.g., ECAP), or thermomechanical treatments (solution annealing, cold working, and aging). This alloy can be considered a functional material,
Sasso M.   +6 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

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