Results 91 to 100 of about 21,592,139 (246)
Materials & DesignA novel TiZrHfTaMo refractory high-entropy alloy (RHEA) was developed by adding Molybdenum to the TiZrHfTa system to enhance its mechanical properties.
Muhammad Abubaker Khan +7 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
A novel method for severe plastic deformation at high strain rate
EPJ Web of Conferences, 2018 Severe plastic deformation (SPD) processing is defined as any method of forming under an extensive hydrostatic pressure that may be used to impart a very high strain to a bulk solid without any significant change in dimensions of the sample, producing ...
Lanjewar Harishchandra +2 more
doaj +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
High Strain-Rate Material Model Validation for Laser Peening Simulation
The Journal of Engineering, 2015 Finite element modeling can be a powerful tool for predicting residual stresses induced by laser peening; however the sign and magnitude of the stress predictions depend strongly on how the material model captures the high strain rate response.
Kristina Langer +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
What do we currently know from in vivo bone strain measurements in humans? [PDF]
, 2011 Bone strains are the most important factors for osteogenic adaptive responses. During the past decades, scientists have been trying to describe the relationship between bone strain and bone osteogenic responses quantitatively. However, only a few studies
Rittweger, Jörn +2 more
core
The strain-rate sensitivity of high-strength high-toughness steels. [PDF]
, 2006 The present study examines the strain-rate sensitivity of four high strength, high-toughness alloys at strain rates ranging from 0.0002 s-1 to 200 s-1: Aermet 100, a modified 4340, modified HP9-4-20, and a recently developed Eglin AFB steel alloy, ES-1c.
Dilmore, M.F. (AFRL/MNMW, Eglin AFB, FL) +2 more
core +1 more source
Tensile Strength of Brittle Materials in High Strain Rate Processes
Engineering Transactions, 1988 Assuming that high strain rate tensile tests lead to brittle fracture (no slip mechanisms participate in the process), the phenomenon of strength growth in very fast processes is attributed to thermal vibrations of crystal lattice.
K.M. Mianowski
doaj