Results 81 to 90 of about 21,592,139 (246)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Determining the effect of strain rate on the fracture of sheet steel [PDF]
A key challenge for the automotive industry is to reduce vehicle mass without compromising on crash safety. To achieve this, it is necessary to model local failure in a material rather than design to the overly conservative criteria of total elongation
Beaumont, Richard Adrian
core
Mechanical Behavior of a High-Strength Austenitic Steel Under Dynamical Biaxial Loading
107115Uniaxial and biaxial experiments were carried out on the high strength austenitic steel X 2 CrNiMnMoNNb 21 16 5 3 at room temperature in the strain rate range from 10-5 up to 102 s-1.
Staskewitsch, Ewald S., Stiebler, K.
core +1 more source
Effect of high strain rate on micro-indentation test in pure aluminum
EPJ Web of Conferences, 2012 The indentation properties of pure aluminum (99.9%, 3N aluminum) and high purity aluminum (99.999%, 5N aluminum) with respect to the strain rate dependence of strength are experimentally investigated in order to clarify the effect of strain rate on the ...
Kobayashi H. +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Strain-rate effects for high-strain-rate computations
, 2006 This paper examines the effect of strain rates for computations involving high strain-rates, beyond $10^{3}$ s$^{ - 1}$. Although it is generally agreed that there is an enhanced rate effect at these higher rates, there is uncertainty regarding the ...
A.E. Nicholls +3 more
core +1 more source
, 2022 With the assistance of an ultrafast time-resolved synchrotron radiation wide-angle X-ray diffraction technique and a homemade hyphenated high-speed tensile apparatus, structural evolutions in the crystalline domain of polybutene-1 (PB-1) are elucidated ...
Wancheng Yu +13 more
core +1 more source