Results 71 to 80 of about 2,568,150 (244)

Validating performance of automotive materials at high strain rate for improved crash design [PDF]

open access: yes, 2006
This paper investigates sources of performance variability in high velocity testing of automotive crash structures. Sources of variability, or so called noise factors, present in a testing environment, arise from uncertainty in structural properties ...
Bardenheier, R.   +6 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

High-strain-rate superplasticity in oxide ceramics

open access: yesScience and Technology of Advanced Materials, 2007
Factors limiting the strain rate of superplastic deformation in ceramic materials are discussed on the basis of existing models and experimental results concerning high-temperature plastic deformation, intergranular cavitation and dynamic grain growth ...
Keijiro Hiraga, Byung-Nam Kim, Koji Morita, Hidehiro Yoshida, Tohru S. Suzuki and Yoshio Sakka
doaj  

Characterisation of the high strain rate behaviour of tubular materials

open access: yesEPJ Web of Conferences, 2018
Airbag gas generators used in the automotive industry are often fabricated from tubular materials. The present work deals with the development of split Hopkinson tensile bar (SHTB) tests for tubular samples. Tubular specimens were machined from the tubes.
Caisso Camille   +4 more
doaj   +1 more source

Modelling of aluminium sheet forming at elevated temperatures [PDF]

open access: yes, 2004
The formability of Al–Mg sheet can be improved considerably, by increasing the temperature. By heating the\ud sheet in areas with large shear strains, but cooling it on places where the risk of necking is high, the limiting drawing ratio\ud can be ...
Boogaard, A.H. van den, Huetink, J.
core   +3 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

open access: yesFEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li   +6 more
wiley   +1 more source

High strain rate micro-compression for crystal plasticity constitutive law parameters identification

open access: yesMaterials & Design, 2020
Microcompression tests were performed on single crystal copper micropillars at 10−2 s−1 and 102 s−1 in the [100], [110] and [111] orientations, to provide inputs for crystal plasticity strain rate sensitive parameters inverse identification.
S. Breumier   +4 more
doaj   +1 more source

Size effects and dislocation patterning in two-dimensional bending

open access: yes, 2006
We perform atomistic Monte Carlo simulations of bending a Lennard-Jones single crystal in two dimensions. Dislocations nucleate only at the free surface as there are no sources in the interior of the sample.
Selinger, Robin L. B.   +1 more
core   +2 more sources

Home - About - Disclaimer - Privacy