Results 51 to 60 of about 1,415,532 (265)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Strain hardenability of a gradient metallic alloy under high-strain-rate compressive loading
Materials & Design, 2019 Subjected to an impact loading, metallic alloys usually display strain softening due to the highly localized shear deformation accompanied by temperature rise, which causes the decrease of resistance to an applied loading and even catastrophic failure ...
Jitang Fan, Minqiang Jiang
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Characterisation of the high strain rate behaviour of tubular materials
EPJ Web of Conferences, 2018 Airbag gas generators used in the automotive industry are often fabricated from tubular materials. The present work deals with the development of split Hopkinson tensile bar (SHTB) tests for tubular samples. Tubular specimens were machined from the tubes.
Caisso Camille +4 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
High-strain-rate superplasticity in oxide ceramics
Science and Technology of Advanced Materials, 2007 Factors limiting the strain rate of superplastic deformation in ceramic materials are discussed on the basis of existing models and experimental results concerning high-temperature plastic deformation, intergranular cavitation and dynamic grain growth ...
Keijiro Hiraga, Byung-Nam Kim, Koji Morita, Hidehiro Yoshida, Tohru S. Suzuki and Yoshio Sakka
doaj
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
High Strain Rate Compaction of Porous Materials – Experiments and Modelling
EPJ Web of Conferences, 2018 Porosity can be found in many forms in common materials, either naturally occurring such as wood, or introduced by a manufacturing process. Applications for such materials include impact protection and energy absorption, which require a good ...
Cotton Matthew, Maw John
doaj +1 more source