Results 61 to 70 of about 1,415,532 (265)
High strain rate micro-compression for crystal plasticity constitutive law parameters identification
Materials & Design, 2020 Microcompression tests were performed on single crystal copper micropillars at 10−2 s−1 and 102 s−1 in the [100], [110] and [111] orientations, to provide inputs for crystal plasticity strain rate sensitive parameters inverse identification.
S. Breumier +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Modeling strain rate sensitivity and high temperature deformation of Mg-3Al-1Zn alloy
Journal of Magnesium and Alloys, 2019 Increasing the plastic deformation temperature of Mg alloys results in higher strain rate sensitivity, easier activation of secondary slip modes, and impeded twinning. In this study, the strain rate sensitivity is estimated for each deformation mode, and
Adrien Chapuis, Qing Liu
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
High Strain Rate Deformation Behavior of Gradient Rolling AZ31 Alloys
MetalsA dynamic impact test was performed on as-rolled AZ31 alloys with gradient microstructure under various strains. The microstructural evolution and mechanical properties were systematically investigated.
Yingjie Li +8 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Materials & DesignA novel TiZrHfTaMo refractory high-entropy alloy (RHEA) was developed by adding Molybdenum to the TiZrHfTa system to enhance its mechanical properties.
Muhammad Abubaker Khan +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source