Results 101 to 110 of about 4,094,018 (318)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

SIMOX, a silicon-technology for high temperature

, 2022
S.12.1-12.10Today the most advanced technology for monolithically integrating electronic circuitry is the silicon technology. This technology is characterized by very fast increasing integration density and also by an increasing complexity of the ...
Burbach, G.
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Rhenium exchange current density and transfer coefficient in the KF-KBF4-B2O3 molten salt

Journal of Electrochemical Science and Engineering
The present paper is devoted to the study of the exchange current density of Re transfer in the high-temperature molten salt system using the Tafel dependencies.
Aleksandr A. Chernyshev, Alexey Apisarov, Andrey Isakov, Yury Zaikov   +3 more
doaj   +1 more source

Energy recovery in the high temperature furnace using a high-emittance fiber (HEF) unit

Nihon Kikai Gakkai ronbunshu, 2016
We have studied the energy recovery effect in high-temperature furnace using a high-emittance fiber (HEF) unit. Previous studies have shown that energy recovery effect occurs as placing the HEF unit perpendicular to the gas flow.
Takumi KOJIMA, Jun SAKAI, Makoto SHIMIZU, Fumitada IGUCHI, Hiroo YUGAMI, Hironaga IGUCHI, Terumi HISAYUKI, Narihito NAKAGAWA, Takemi YAMAMURA   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

High Pressure Enhances the Growth Rate of the Thermophilic Archaebacterium Methanococcus thermolithotrophicus without Extending Its Temperature Range

, 1988
Temperature and hydrostatic pressure are essential in determining the assemblage of species in their specific biotopes. To evaluate the effect of high pressure on the range of viability of thermophiles, the pressure and temperature dependence of the ...
Lüdemann, Hans-Dietrich, Jaenicke, Rainer, Stetter, Karl Otto, König, Helmut, Bernhardt, Günther   +4 more
core   +1 more source

High-temperature-oxidation-induced ordered structure in Inconel 939 superalloy exposed to oxy-combustion environments [PDF]

, 2013
In the integrated oxy-fuel combustion and turbine power generation system, turbine alloys are exposed to high temperature and an atmosphere comprised of steam, CO2 and O2.
Jinxi Zhu (5371973), Zhu, Jingxi, David E. Laughlin (3703957), Paul D. Jablonski (5371976), Sridhar, Seetharaman, Holcomb, Gordon R., Laughlin, David E., Jablonski, Paul D., Seetharaman Sridhar (5371967), Noel Nuhfer (3895054), Nuhfer, Thomas, Gordon R. Holcomb (5371970), Wise, Adam, Adam Wise (3880498)   +13 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

High temperature design approaches for welds

, 2003
The operational and plant assessment experience indicates that in the majority of cases where high temperature failure occurs, defects predominate in the vicinity of weldments.
Dogan, B., GKSS-Forschungszentrum Geesthacht GmbH (Germany)   +1 more
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