Results 111 to 120 of about 7,910,907 (308)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

High-temperature gas/liquid stress relaxometers [PDF]

open access: yes, 1974
Two relaxometers allow testing of elastomers in various fluids. First relaxometer uses fork-like loading spacer interposed between loading lever and support ring, so that sample is stretched predetermined amount.
Kalfayan, S. H., Silver, R. H.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

High-Temperature (Cu,C)Ba2Ca3Cu4Oy Superconducting Films with Large Irreversible Fields Grown on SrLaAlO4 Substrates by Pulsed Laser Deposition

open access: yesCrystals
(Cu,C)Ba2Ca3Cu4Oy is a nontoxic cuprate superconducting material with a superconducting transition temperature of about 116 K. Recently, it was found that bulk samples of this material synthesized under high pressure hold the highest irreversibility line
Yugang Li   +4 more
doaj   +1 more source

High temperature stress-strain analysis [PDF]

open access: yes, 1984
The objectives are threefold: to assist in developing predictive tools needed to improve design analyses and procedures for the efficient and accurate prediction of burner liner structural performance and response; to calibrate, validate, and evaluate ...
Thompson, R. L.
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Passivation of high temperature superconductors [PDF]

open access: yes, 1991
The surface of high temperature superconductors such as YBa2Cu3O(7-x) are passivated by reacting the native Y, Ba and Cu metal ions with an anion such as sulfate or oxalate to form a surface film that is impervious to water and has a solubility in water ...
Vasquez, Richard P.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Effect of Y on Oxidation Behavior of Directionally Solidified Ni-Based Single-Crystal Superalloy

open access: yesChinese Journal of Mechanical Engineering
The effect of yttrium (Y) addition on the oxidation behavior of a Ni-based directionally solidified single-crystal superalloy is investigated in this study. Isothermal oxidation tests for samples with different levels of Y addition are conducted at 1100 °
Zihan Zhao   +4 more
doaj   +1 more source

High temperature testing apparatus Patent [PDF]

open access: yes, 1965
Test apparatus for determining mechanical properties of refractory materials at high temperatures in vacuum or inert ...
Sikora, P. F.
core   +1 more source

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