Results 91 to 100 of about 1,120,137 (290)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Texture Evolution of AZ31 Magnesium Alloy Sheet at High Strain Rates [PDF]

, 2010
In the current contribution the mechanical behaviour at high strain rates of AZ31 magnesium alloy sheet is studied. Uniaxial deformation properties were studied by means of tensile split Hopkinson pressure bar (SHPB) at different temperatures.
Hurtado, I., Letzig, D., Gálvez, F., Yi, S., Pérez-Prado, M. T., Dudamell, N. V., Pérez Prado, María Teresa, Dudamell, N.V., Ulacia, I., Gálvez Díaz-Rubio, Francisco   +9 more
core   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

High Pressure Elastic Behavior of Synthetic Mg3Y2(SiO4)3 Garnet up to 9 GPa

Advances in Materials Science and Engineering, 2013
The compression behavior of synthetic magnesium- (Mg-) yttrium (Y) garnet Mg3Y2(SiO4)3 has been investigated upto about 8.79 GPa at 300 K using in situ angle-dispersive X-ray diffraction and a diamond anvil cell at the beamline X17C, National Synchrotron
Dawei Fan, Maining Ma, Shuyi Wei, Zhiqiang Chen, Hongsen Xie   +4 more
doaj   +1 more source

High-Pressure High-Temperature XAFS Investigation on HgTe [PDF]

Le Journal de Physique IV, 1997
X-ray absorption measurements at the L3 edge of Hg in solid and liquid HgTe have been performed under high-temperature and high-pressure up to 1000 K and 3 GPa using a large volume Paris-Edinburgh press. EXAFS spectra have been analyzed with GNXAS approach.
Katayama, Y., Mezouar, M., Itié, J., Besson, J., Syfosse, G., Le Fèvre, P., Di Cicco, A.   +6 more
openaire   +3 more sources

Numerical Modeling of MILD Combustion at High Pressure to Predict the Optimal Operating Conditions [PDF]

, 2017
This Chapter presents numerical simulation on MILD combustion operating at high pressure. Influence of preheat and dilution of oxidizer and operating pressure on stabilization of MILD combustion are presented.
Vanteru, Mahendra Reddy, Roberts, William L.   +1 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Electrical anisotropy calculation of the continental crust by resistor network-based circuit simulationsGitHub

Applied Computing and Geosciences
Electrical anisotropy has been broadly observed by magnetotelluric (MT) surveys in the continental crust. It is proposed to be caused by rock microfabrics, lithologic layering, or oriented alignment of fluid or melt in rocks, whereas the validity of ...
Song Luo, Haiying Hu, Lidong Dai
doaj   +1 more source

Density, magnetic properties and sound velocities of iron-rich materials at high temperature and high pressure [PDF]

, 2010
Understanding the composition of Earth’s inner core is crucial for revealing the mechanisms of core formation and the evolution of Earth. The presence of light elements in the Earth’s inner core has been indicated in recent studies, based on the mismatch
Gao, Lili
core