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Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening. [PDF]

Elife
Zhou H, Zhou T, Yu W, Liu L, Ko Y, Johnson KA, Wilson IA, Schultz PG, Bollong MJ.   +8 more
europepmc   +1 more source

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High-Throughput Crystallization Screening

2014
Protein structure determination by X-ray crystallography is dependent on obtaining a single protein crystal suitable for diffraction data collection. Due to this requirement, protein crystallization represents a key step in protein structure determination.
Tatiana, Skarina, Xiaohui, Xu, Elena, Evdokimova, Alexei, Savchenko   +3 more
openaire   +2 more sources

High-throughput screening: designer screens

Nature Methods, 2009
Some researchers say an eighty-year-old statistical method can make setting up and analyzing high-throughput screens and large-scale experiments faster and more efficient. So why are more biologists not flocking to use this tool?
openaire   +2 more sources

High Throughput Screening Informatics

Combinatorial Chemistry & High Throughput Screening, 2008
High throughput screening (HTS), an industrial effort to leverage developments in the areas of modern robotics, data analysis and control software, liquid handling devices, and sensitive detectors, has played a pivotal role in the drug discovery process, allowing researchers to efficiently screen millions of compounds to identify tractable small ...
openaire   +2 more sources

High-throughput screening technologies

2003
In the past 5 years the world of high-throughput screening (HTS), which targets lead discovery for both pharmaceutical and agrochemical applications, is in a highly rapid developmental stage. Today, restructuring the drug discovery programs to develop highest performance is a key issue of pharmaceutical companies.
openaire   +2 more sources

High-Throughput Screening

2014
Ion channels are a class of proteins that are attractive human, animal, and crop health targets. Ion channels can be considered high-gain (physiologically speaking), high-reward (therapeutic benefit) and high technology (difficult assay development) drug targets.
Alexander Böcker, Sabine Schaertl, Stephen D. Hess   +2 more
openaire   +2 more sources

High-throughput screening

Drug Discovery Today, 2000
, Grepin, , Pernelle
openaire   +2 more sources

High-throughput Screening

2006
Richard Nelson, Carol Ann Homon
  +4 more sources