Results 1 to 10 of about 19,076,274 (291)

Schisandrin B Exerts Radiosensitizing Effects on Breast Cancer via Dual Mechanisms of Cell Cycle/DNA Repair and Gut Microbiota-Immune Axis Modulation

Pharmaceuticals
Background/Objectives: Schisandrin B (Sch B), a bioactive lignan of Schisandra chinensis has been commonly investigated for its antitumor activities, yet its radiosensitizing effect and mechanism remain unclear.
Yanhua Fang, Mengxuan Wang, Man Tong, Yue Wang, Zeshuo Feng, Ruoyu Wang, Zhe Wang, Lingyun Jia, Shanshan Liang   +8 more
doaj   +1 more source

Patient-derived organoid elucidates the identical clonal origin of bilateral breast cancer with diverse molecular subtypes

Frontiers in Oncology
Bilateral breast cancer (BBC), an infrequent breast cancer subtype, has primarily been studied in terms of incidence, prognosis, and through comparative analysis of synchronous (SBBC) and metachronous (MBBC) manifestations.
Zhongbin Han, Zhongbin Han, Liangxue Yao, Yanhua Fang, Sijing Chen, Sijing Chen, Ruiqing Lian, Yongqiang Yao, Hongsheng Chen, Xuening Ji, Weiting Yu, Zhe Wang, Ruoyu Wang, Ruoyu Wang, Shanshan Liang   +14 more
doaj   +1 more source

Hyperphosphorylated tau-based Alzheimer’s Disease drug discovery: Identification of inhibitors of tau aggregation and cytotoxicity

SLAS Discovery
Alzheimer’s disease (AD) is a neurodegenerative disorder that affects more than 30 million people worldwide. Underlying the progressive decline of cognitive functions are the neurofibrillary tangles (NFTs) in neurons of the brain.
Hsiao-Tien Hagar, Virneliz Fernandez-Vega, Kuang-Wei Wang, Luis M. Ortiz Jordan, Justin Shumate, Louis Scampavia, April Sweet Tapayan, Hien M Nguyen, Timothy P. Spicer, Min-Hao Kuo   +9 more
doaj   +1 more source

Targeting EMT using low-dose Teniposide by downregulating ZEB2-driven activation of RNA polymerase I in breast cancer

Cell Death and Disease
Metastatic dissemination from the primary tumor is a complex process that requires crosstalk between tumor cells and the surrounding milieu and involves the interplay between numerous cellular-signaling programs.
Brandon J. Metge, Heba Allah M. Alsheikh, Sarah C. Kammerud, Dongquan Chen, Devika Das, N. Miranda Nebane, J. Robert Bostwick, Lalita A. Shevde, Rajeev S. Samant   +8 more
doaj   +1 more source

High-Throughput Screening for Accelerated Oxide Glass Discovery. [PDF]

Adv Sci (Weinh)
Seibel-Geraschenko I, Slowik J, Scheffler F, Duval A, Krishnan NMA, Wondraczek L.   +5 more
europepmc   +1 more source

Retraction Note: Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway

Cell Death and Disease
Ting Xiao, Weilong Zhong, Jianmin Zhao, Baoxin Qian, Huijuan Liu, Shuang Chen, Kailiang Qiao, Yueyang Lei, Shumin Zong, Hongzhi Wang, Yuan Liang, Heng Zhang, Jing Meng, Honggang Zhou, Tao Sun, Yanrong Liu, Cheng Yang   +16 more
doaj   +1 more source

High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency. [PDF]

Front Plant Sci
Van Buyten M, Audenaert D, Beeckman T, Motte H.   +3 more
europepmc   +1 more source

A Fluorescence-Based High-Throughput Screening Method for EGFR Inhibitors Using an EGFR-Targeted Environment-Sensitive Fluorescent Probe. [PDF]

J Anal Methods Chem
Wang LX, Cuan XD, Chen XY, Wang XJ.
europepmc   +1 more source

Generation of high-performance human cardiomyocytes and engineered heart tissues from extended pluripotent stem cells

Cell Discovery, 2022
Li Li, Zhongjun Wan, Ruxiang Wang, Yuxin Zhao, Yida Ye, Pengcheng Yang, Yan Qi, Wei Jiang, Lin Cai, Donghui Zhang   +9 more
doaj   +1 more source

Domain-Aware Feature Engineering for Prediction of Molecular Optical Interference in High-Throughput Screening. [PDF]

J Chem Inf Model
Stefaniak F.
europepmc   +1 more source