Computational screening of magnetocaloric alloys [PDF]
, 2020 An exciting development over the past few decades has been the use of high-throughput computational screening as a means of identifying promising candidate materials for a variety of structural or functional properties.
Bocarsly, Joshua D +2 more
core +2 more sources
Cell Discovery, 2023 How cells adapt their gene expression to nutritional changes remains poorly understood. Histone H3T11 is phosphorylated by pyruvate kinase to repress gene transcription.
Xinyu Zhang +7 more
doaj +1 more source
High throughput biodegradation-screening test to prioritize and evaluate chemical biodegradability [PDF]
, 2017 Comprehensive assessment of environmental biodegradability of pollutants is limited by the use of low throughput systems. These are epitomized by the Organisation for Economic Cooperation and Development (OECD) Ready Biodegradability Tests (RBTs), where ...
Martin, Timothy J. +5 more
core +2 more sources
Scalable production of iPSC-derived human neurons to identify tau-lowering compounds by high-content screening [PDF]
, 2017 Lowering total tau levels is an attractive therapeutic strategy for Alzheimer's disease and other tauopathies. High-throughput screening in neurons derived from human induced pluripotent stem cells (iPSCs) is a powerful tool to identify tau-targeted ...
Chen, Robert +12 more
core +3 more sources
Clinical application of high throughput molecular screening techniques for pharmacogenomics. [PDF]
, 2011 Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples.
Schrijver, Iris, Wiita, Arun P
core +1 more source
RNA-aptamers-in-droplets (RAPID) high-throughput screening for secretory phenotypes. [PDF]
, 2017 Synthetic biology and metabolic engineering seek to re-engineer microbes into living foundries for the production of high value chemicals. Through a design-build-test cycle paradigm, massive libraries of genetically engineered microbes can be constructed
Abate, Adam +8 more
core +1 more source
High-throughput screening in larval zebrafish identifies novel potent sedative-hypnotics [PDF]
, 2018 BACKGROUND: Many general anesthetics were discovered empirically, but primary screens to find new sedative-hypnotics in drug libraries have not used animals, limiting the types of drugs discovered.
Brown, Lauren E. +12 more
core +1 more source
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells [PDF]
, 2013 Hypoxia inducible factor-1 (HIF-1) is a heterodimeric transcription factor that acts as the master regulator of cellular response to reduced oxygen levels, thus playing a key role in the adaptation, survival and progression of tumors.
Court, William +11 more
core +1 more source
Upscaling the surveillance of tick-borne pathogens in the French Caribbean Islands [PDF]
, 2020 Despite the high burden of vector-borne disease in (sub)tropical areas, few information are available regarding the diversity of tick and tick-borne pathogens circulating in the Caribbean.
Albina, Emmanuel +9 more
core +3 more sources
Frontiers in Pharmacology, 2022 Aims: Reports of hepatitis in children during the coronavirus disease 2019 (COVID-19) pandemic garnered worldwide attention. The most probable culprits are adenovirus and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Yanhua Fang +5 more
doaj +1 more source