Results 21 to 30 of about 19,076,274 (291)

Extracellular matrix stiffness mediates radiosensitivity in a 3D nasopharyngeal carcinoma model

Cancer Cell International, 2022
Purpose Radiotherapy is one of the essential treatment modalities for nasopharyngeal carcinoma (NPC), however, radioresistance still poses challenges.
Yanhua Fang, Shanshan Liang, Jianong Gao, Zhe Wang, Cheng Li, Ruoyu Wang, Weiting Yu   +6 more
doaj   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

Microfluidic Technologies for High-Throughput Screening Applications [PDF]

, 2003
In this thesis, I present a strategy for the design and development of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed in prokaryotic hosts, where a few point mutations at the DNA level ...
Thorsen, Todd Addison
core   +1 more source

nrijs/Automated-Structural-Activity-Screening-of--Diketonate-Assemblies-with-High-Throughput-Ion-Mobility: v1.0

, 2023
Automated Structural Activity Screening of β-Diketonate Assemblies with High-Throughput Ion Mobility - Mass ...
OLWatUNSW
core   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E, Mansour Nuha R, Bleicher Leo S, Hopkins Andrew L, Benn Alex E, Paveley Ross A, Gilbert Ian H, Gilbert, Ian H.; id_orcid, Bickle Quentin D   +53 more
core   +2 more sources

Complementary approaches to target human respiratory syncytial virus using small molecule ligands [PDF]

, 2012
In the current project, situated at the interface of chemistry and virology, complementary drug discovery approaches (high-throughput screening and structurebased drug design) have been exploited in order to discover novel small molecule inhibitors of ...
Lardeau, Charles-Hugues Claude Jean
core   +5 more sources

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]

, 2011
Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G., Brown, Elaine, Thomson, Graeme, Blake, David G., Malone, Kirk, Turner, Nicholas J., Grant, Karen, Mottram, Jeremy C., Walkinshaw, Malcolm D., Nowicki, Matthew W.   +9 more
core   +3 more sources

Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis

Frontiers in Pharmacology, 2022
Aims: Reports of hepatitis in children during the coronavirus disease 2019 (COVID-19) pandemic garnered worldwide attention. The most probable culprits are adenovirus and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Yanhua Fang, Lingling Zhang, Zhe Wang, Ruoyu Wang, Ruoyu Wang, Shanshan Liang   +5 more
doaj   +1 more source

The Future of High-Throughput Screening

SLAS Discovery, 2008
High-throughput screening (HTS) is a well-established process in lead discovery for pharma and biotech companies and is now also being set up for basic and applied research in academia and some research hospitals. Since its first advent in the early to mid-1990s, the field of HTS has seen not only a continuous change in technology and processes but ...
Lorenz M, Mayr, Peter, Fuerst
openaire   +2 more sources

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source