Results 21 to 30 of about 16,617,738 (336)
Journal of biomolecular screening, 1999 The ability to identify active compounds ("hits") from large chemical libraries accurately and rapidly has been the ultimate goal in developing high-throughput screening (HTS) assays.
Ji-Hu Zhang, T. Chung, K. Oldenburg
semanticscholar +1 more source
Microfluidic Technologies for High-Throughput Screening Applications [PDF]
, 2003 In this thesis, I present a strategy for the design and development of microfluidic devices for high-throughput screening applications, such as mutant enzyme libraries expressed in prokaryotic hosts, where a few point mutations at the DNA level ...
Thorsen, Todd Addison
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High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase [PDF]
, 2011 Background: Leishmania species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs). Cdc2-related kinase 3 (CRK3), an essential CDK in Leishmania and functional orthologue of human CDK1, can form ...
Walker, Roderick G. +9 more
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Comprehensive Survey of Consensus Docking for High-Throughput Virtual Screening
Molecules, 2022 The rapid advances of 3D techniques for the structural determination of proteins and the development of numerous computational methods and strategies have led to identifying highly active compounds in computer drug design.
C. Blanes-Mira +5 more
semanticscholar +1 more source
npj Computational Materials, 2021 Here, we report a density functional theory (DFT)-based high-throughput screening method to successfully identify a type of alloy nanoclusters as the electrocatalyst for hydrogen evolution reaction (HER).
Xinnan Mao +5 more
semanticscholar +1 more source
High-Throughput Transcriptomics Platform for Screening Environmental Chemicals.
Toxicological Sciences, 2021 New approach methodologies (NAMs) that efficiently provide information about chemical hazard without using whole animals are needed to accelerate the pace of chemical safety assessments.
J. Harrill +8 more
semanticscholar +1 more source
Identification of selective inhibitors of cancer stem cells by high-throughput screening
Cell, 2009 Summary Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture.
Piyush B. Gupta +6 more
semanticscholar +1 more source
The impact of microfluidics in high-throughput drug-screening applications
Biomicrofluidics, 2022 Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin preclinical tests proceed to clinical trials.
Paola De Stefano, E. Bianchi, G. Dubini
semanticscholar +1 more source
The Future of High-Throughput Screening
SLAS Discovery, 2008 High-throughput screening (HTS) is a well-established process in lead discovery for pharma and biotech companies and is now also being set up for basic and applied research in academia and some research hospitals. Since its first advent in the early to mid-1990s, the field of HTS has seen not only a continuous change in technology and processes but ...
Lorenz M, Mayr, Peter, Fuerst
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New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]
, 2015 Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa +26 more
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