Results 11 to 20 of about 465,259 (306)

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Barroso, Vanessa, Drewry, David H., Kessler, Albane, Pilar Manzano, M., Cotillo, Ignacio, Roquero, Irene, Alonso-Padilla, Julio, Bardera, Ana I., Navarro, Miguel, Manzano, Pilar, Brown, James R., Sherstnev, Alexander, Alvarez, Emilio, Rodríguez López, Ana, Fiandor, Jose M., Julio Martin, J., Dios-Antón, Francisco de, Kumar, Vinod, Peña, Imanol, Martin, José Julio, Gray, David W., Gray, David W.; id_orcid, Rodriguez, Ana, Navarro, M., Cantizani, Juan, de Dios-Anton, Francisco, Colmenarejo, Gonzalo   +26 more
core   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +1 more source

nrijs/Automated-Structural-Activity-Screening-of--Diketonate-Assemblies-with-High-Throughput-Ion-Mobility: v1.0

, 2023
Automated Structural Activity Screening of β-Diketonate Assemblies with High-Throughput Ion Mobility - Mass ...
OLWatUNSW
core   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +1 more source

Theory-Enabled High-Throughput Screening of Ion Dissociation Explains Conductivity Enhancements in Diluted Ionic Liquid Mixtures

, 2023
The growing demand for room-temperature ionic liquids (RTILs) for energy applications necessitates the development of an efficient screening platform. In this study, we have successfully developed a fully automated high-throughput RTIL screening platform
Amey, Thorat, Jindal K, Shah, Rohan, Sartape, Rohit, Chauhan, Meenesh R, Singh   +4 more
core   +1 more source

The Future of High-Throughput Screening

SLAS Discovery, 2008
High-throughput screening (HTS) is a well-established process in lead discovery for pharma and biotech companies and is now also being set up for basic and applied research in academia and some research hospitals. Since its first advent in the early to mid-1990s, the field of HTS has seen not only a continuous change in technology and processes but ...
Lorenz M, Mayr, Peter, Fuerst
openaire   +2 more sources

High Throughput Centrifugal Adhesion Screening Test for Soft Materials

, 2021
High-throughput screening of material mechanical properties has the potential to transform material science research in both aiding in material discovery and developing predictive models.
Kenneth, Shull, Yusu, Chen, Johanna, Kann, Carolyn, Mills, Danielle, Tullman-Ercek, Muzhou, Wang, Qifeng, Wang   +6 more
core   +1 more source

Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis

Frontiers in Pharmacology, 2022
Aims: Reports of hepatitis in children during the coronavirus disease 2019 (COVID-19) pandemic garnered worldwide attention. The most probable culprits are adenovirus and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Yanhua Fang, Lingling Zhang, Zhe Wang, Ruoyu Wang, Ruoyu Wang, Shanshan Liang   +5 more
doaj   +1 more source

Codelivery of HBx-siRNA and Plasmid Encoding IL-12 for Inhibition of Hepatitis B Virus and Reactivation of Antiviral Immunity

Pharmaceutics, 2022
Chronic hepatitis B is a critical cause of many serious liver diseases such as hepatocellular carcinoma (HCC). The main challenges in hepatitis B treatment include the rebound of hepatitis B virus (HBV)-related antigen levels after drug withdrawal and ...
Yan Mu, Xiao-He Ren, Di Han, Ying-Ying Guan, Pei-Ling Liu, Si-Xue Cheng, Hong Liu   +6 more
doaj   +1 more source