Results 41 to 50 of about 16,617,738 (336)

nrijs/Automated-Structural-Activity-Screening-of--Diketonate-Assemblies-with-High-Throughput-Ion-Mobility: v1.0

, 2023
Automated Structural Activity Screening of β-Diketonate Assemblies with High-Throughput Ion Mobility - Mass ...
OLWatUNSW
core   +1 more source

A high-throughput human tissue model for respiratory viruses: Automating the use of human airway epithelial tissues for faster drug discovery

SLAS Discovery
Animal testing for drug discovery is expensive and the decision to test a compound in an in vivo model should be carefully considered. In addition, the FDA Modernization Act has resulted in the allowance of alternatives to animal models for testing the ...
N. Miranda Nebane, Andrew Reece, Lynn Rasmussen, Melinda Sosa, Pedro Ruiz, Sara M. Cabrera, Yohanka Martinez-Gzegozewska, Paige Vinson   +7 more
doaj   +1 more source

Role of matrix metalloproteinases in diabetic foot ulcers: Potential therapeutic targets

Frontiers in Pharmacology, 2022
Diabetic foot ulcers (DFUs) are pathological states of tissue destruction of the foot or lower extremity in diabetic patients and are one of the serious chronic complications of diabetes mellitus.
Kang Fu, Xueyao Zheng, Yuhan Chen, Yuhan Chen, Liuying Wu, Liuying Wu, Zhiming Yang, Zhiming Yang, Xu Chen, Xu Chen, Wei Song, Wei Song   +11 more
doaj   +1 more source

High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses

Journal of Virology, 2019
Currently, there is no approved therapy to treat coronavirus infection; therefore, broad-spectrum inhibitors of emerging and endemic CoVs are needed. Based on our high-throughput screening assay using a compound library, we identified seven compounds ...
Liang Shen, Jun-Wei Niu, Chun-Hua Wang, Baoying Huang, Wen-Ling Wang, N. Zhu, Yao Deng, Huijuan Wang, F. Ye, S. Cen, W. Tan   +10 more
semanticscholar   +1 more source

High-throughput screening platform for solid electrolytes combining hierarchical ion-transport prediction algorithms

Scientific Data, 2020
The combination of a materials database with high-throughput ion-transport calculations is an effective approach to screen for promising solid electrolytes. However, automating the complicated preprocessing involved in currently widely used ion-transport
Bing He, Shuting Chi, Anjiang Ye, Penghui Mi, Liwen Zhang, Bo-Wei Pu, Zhe-Yi Zou, Yunbing Ran, Qian Zhao, Da Wang, Wen-Qing Zhang, Jing-Tai Zhao, S. Adams, M. Avdeev, Siqi Shi   +14 more
semanticscholar   +1 more source

High throughput screens yield small molecule inhibitors of Leishmania CRK3:CYC6 cyclin-dependent kinase [PDF]

, 2011
<p><b>Background:</b> <i>Leishmania</i> species are parasitic protozoa that have a tightly controlled cell cycle, regulated by cyclin-dependent kinases (CDKs).
Mottram Jeremy C., Thomson, Graeme, Mottram, JC, Grant Karen M., Turner, N.J., Malcolm D. Walkinshaw, Malone, Kirk, Turner, Nicholas J., Nicholas J Turner, Jeremy C. Mottram, Karen M. Grant, Walker, Roderick G., Kita, K, Graeme Thomson, Malone Kirk, Karen M Grant, Grant, Karen, Nicholas J. Turner, Walker, RG, Nowicki, Matthew W., Thomson Graeme, Walkinshaw, M.D., Walkinshaw Malcolm D., David G. Blake, David G Blake, Walker Roderick G., Brown, Elaine, Brown Elaine, Blake David G., Brown, E, Malone, K, Turner Nicholas J., Walkinshaw, MD, Blake, DG, Matthew W. Nowicki, Walker, R.G., Malone, K., Blake, David G., Elaine Brown, Mottram, J.C., Kirk Malone, Walkinshaw, Malcolm D., Matthew W Nowicki, Nowicki, MW, Brown, E., Nowicki Matthew W., Turner, Nicholas J.; id_orcid, Grant, Karen M., Grant, K.M., Mottram, Jeremy C., Roderick G Walker, Thomson, G, Jeremy C Mottram, Roderick G. Walker, Nowicki, M.W., Grant, KM, Blake, D.G., Malcolm D Walkinshaw, Turner, NJ, Thomson, G.   +59 more
core   +2 more sources

Development of a miniaturized 3D organoid culture platform for ultra-high-throughput screening

Journal of Molecular Cell Biology, 2020
The recent advent of robust methods to grow human tissues as 3D organoids allows us to recapitulate the 3D architecture of tumors in an in vitro setting and offers a new orthogonal approach for drug discovery.
Yu-Hong Du, Xingnan Li, Qiankun Niu, Xiulei Mo, Qui Min, Tingxuan Ma, Calvin J. Kuo, H. Fu   +7 more
semanticscholar   +1 more source

Linking a role of lncRNAs (long non-coding RNAs) with insulin resistance, accelerated senescence, and inflammation in patients with type 2 diabetes

Human Genomics, 2018
Background Studying epigenetics is expected to provide precious information on how environmental factors contribute to type 2 diabetes mellitus (T2DM) at the genomic level.
Chandrakumar Sathishkumar, Paramasivam Prabu, Viswanathan Mohan, Muthuswamy Balasubramanyam   +3 more
doaj   +1 more source

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei. [PDF]

, 2014
In the bloodstream of mammalian hosts, the sleeping sickness parasite, Trypanosoma brucei, exists as a proliferative slender form or a nonproliferative, transmissible, stumpy form.
Auer, Manfred, Ivens, A, Matthews, KR, Matthews, Keith R., Collie, I, Ivens, Alasdair, Auer, M, Gray, David, McGregor, Paula, Macgregor, Paula, Matthews, Keith R; id_orcid, Gray, David; id_orcid, Collie, Iain, Shave, S, MacGregor, P, Gray, D, Shave, Steven   +16 more
core   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source