Results 31 to 40 of about 16,617,738 (336)

High throughput preparation and analysis of plastically shaped material samples [PDF]

, 2003
A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. The plurality of samples is then formed into a plurality of films.
Hajduk, Damian, Kolosov, Oleg
core   +4 more sources

Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries

Nature Biotechnology, 2021
Current methods used for measuring amino acid side-chain reactivity lack the throughput needed to screen large chemical libraries for interactions across the proteome.
Miljan Kuljanin, Dylan C. Mitchell, Devin K. Schweppe, Ajami Gikandi, David P. Nusinow, Nathan J. Bulloch, E. Vinogradova, D. L. Wilson, E. Kool, J. Mancias, B. Cravatt, S. Gygi   +11 more
semanticscholar   +1 more source

Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases. [PDF]

, 2012
Sole reliance on one drug, Praziquantel, for treatment and control of schistosomiasis raises concerns about development of widespread resistance, prompting renewed interest in the discovery of new anthelmintics.
Bickle, Quentin D, Bickle, Quentin D., Mansour Nuha R., Gilbert, Ian H, Alex E Benn, Bickle Quentin D., Ian H Gilbert, Nuha R. Mansour (146895), Andrew L. Hopkins (146939), Ivana Mikic (146920), Benn Alex E., Guidi Alessandra, Leo S. Bleicher (146907), Hopkins, Andrew L, Gilbert, Ian H., Bleicher Leo S., Hopkins Andrew L., Guidi, Alessandra, Benn, Alex E., Ivana Mikic, Quentin D. Bickle (146947), Alex E. Benn (146913), Irene Hallyburton (146900), Ian H. Gilbert (146934), Bleicher, Leo S, Alessandra Guidi (146927), Mansour, Nuha R., Paveley, Ross A., Alessandra Guidi, Bleicher, Leo S., Ross A Paveley, Irene Hallyburton, Quentin D Bickle, Hallyburton, Irene, Paveley Ross A., Paveley, Ross A, Mikic Ivana, Nuha R Mansour, Ross A. Paveley (146889), Mansour, Nuha R, Leo S Bleicher, Mikic, Ivana, Hopkins, Andrew L., Andrew L Hopkins, Hallyburton Irene, Gilbert Ian H., Benn, Alex E   +46 more
core   +2 more sources

Potential protective benefits of Schisandrin B against severe acute hepatitis in children during the COVID-19 pandemic based on a network pharmacology analysis

Frontiers in Pharmacology, 2022
Aims: Reports of hepatitis in children during the coronavirus disease 2019 (COVID-19) pandemic garnered worldwide attention. The most probable culprits are adenovirus and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Yanhua Fang, Lingling Zhang, Zhe Wang, Ruoyu Wang, Ruoyu Wang, Shanshan Liang   +5 more
doaj   +1 more source

Comparison of microscopy and Alamar blue reduction in a larval based assay for schistosome drug screening. [PDF]

, 2010
BACKGROUND: In view of the current widespread use of and reliance on a single schistosomicide, praziquantel, there is a pressing need to discover and develop alternative drugs for schistosomiasis.
Bickle, Quentin D, Mansour Nuha R., Nuha R Mansour, Mansour, Nuha R, Bickle Quentin D., Nuha R. Mansour, Quentin D Bickle, Quentin D. Bickle   +7 more
core   +1 more source

High Throughput Centrifugal Adhesion Screening Test for Soft Materials [PDF]

, 2021
High-throughput screening of material mechanical properties has the potential to transform material science research in both aiding in material discovery and developing predictive models.
Kenneth, Shull, Yusu, Chen, Johanna, Kann, Carolyn, Mills, Danielle, Tullman-Ercek, Muzhou, Wang, Qifeng, Wang   +6 more
core   +2 more sources

Theory-Enabled High-Throughput Screening of Ion Dissociation Explains Conductivity Enhancements in Diluted Ionic Liquid Mixtures [PDF]

, 2023
The growing demand for room-temperature ionic liquids (RTILs) for energy applications necessitates the development of an efficient screening platform. In this study, we have successfully developed a fully automated high-throughput RTIL screening platform
Amey, Thorat, Jindal K, Shah, Rohan, Sartape, Rohit, Chauhan, Meenesh R, Singh   +4 more
core   +2 more sources

Codelivery of HBx-siRNA and Plasmid Encoding IL-12 for Inhibition of Hepatitis B Virus and Reactivation of Antiviral Immunity

Pharmaceutics, 2022
Chronic hepatitis B is a critical cause of many serious liver diseases such as hepatocellular carcinoma (HCC). The main challenges in hepatitis B treatment include the rebound of hepatitis B virus (HBV)-related antigen levels after drug withdrawal and ...
Yan Mu, Xiao-He Ren, Di Han, Ying-Ying Guan, Pei-Ling Liu, Si-Xue Cheng, Hong Liu   +6 more
doaj   +1 more source

EIF2S2 is a novel independent prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma

Frontiers in Genetics, 2022
Background: Hepatocellular carcinoma (HCC) is a highly malignant disease with poor prognosis. It is urgent to find effective biomarkers. Eukaryotic Translation Initiation Factor 2 Subunit Beta (EIF2S2) is a subunit of heterotrimeric G protein EIF2, and ...
Jing Liu, Jing Liu, Tongyu Liu, Chuanhao Zhang, Chuanhao Zhang, Jiabei He, Jiabei He, Dong Zhou, Dong Zhou, Zhe Wang, Zhe Wang, Ruoyu Wang, Ruoyu Wang   +12 more
doaj   +1 more source

Machine learning assisted hit prioritization for high throughput screening in drug discovery [PDF]

, 2023
Efficient prioritization of bioactive compounds from high throughput screening campaigns is a fundamental challenge for accelerating drug development efforts.
Lukas, Friedrich, Daniel, Kuhn, Stephan, Sieber, Davide, Boldini   +3 more
core   +2 more sources