Results 91 to 100 of about 1,227,725 (294)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

An Incremental High-Utility Mining Algorithm with Transaction Insertion

open access: yesThe Scientific World Journal, 2015
Association-rule mining is commonly used to discover useful and meaningful patterns from a very large database. It only considers the occurrence frequencies of items to reveal the relationships among itemsets.
Jerry Chun-Wei Lin   +3 more
doaj   +1 more source

Assessing Data Usefulness for Failure Analysis in Anonymized System Logs

open access: yes, 2018
System logs are a valuable source of information for the analysis and understanding of systems behavior for the purpose of improving their performance. Such logs contain various types of information, including sensitive information.
Ciorba, Florina M., Ghiasvand, Siavash
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The effect of pension rules on retirement monetary incentives with an application to pension reforms in Spain [PDF]

open access: yes, 2001
In this work we theoretically disentangle the effects of pension provisions on a variety of financial incentives to retirement, trying to reconcile them with some key Spanish retirement patterns.
Jiménez-Martín, Sergi   +1 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Fast Single Pbase Algoritbm for Utility Mining in Big Data

open access: yesDianxin kexue, 2015
Most of the latest works on utility mining generates a huge number of candidates in dealing with big data,which suffers from the scalability issue.Some work does not generate candidates,but suffers from the efficiency issue due to lack of strong pruning ...
Junqiang Liu   +3 more
doaj   +2 more sources

What I see, what you say: How cross‐method variation sharpens characterization of irritability in early childhood

open access: yesInternational Journal of Methods in Psychiatric Research
Objectives Identification of clinically significant irritability in preschool age is important to implement effective interventions. However, varying informant and measurement methods display distinct patterns.
Alyssa J. Parker   +6 more
doaj   +1 more source

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