Results 91 to 100 of about 1,895,501 (280)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
HI-Tree: Mining High Influence Patterns Using External and Internal Utility Values
, 2015 We propose an efficient algorithm, called HI-Tree, for mining high influence patterns for an incremental dataset. In traditional pattern mining, one would find the complete set of patterns and then apply a post-pruning step to it.
Yun Sing Koh +3 more
core +1 more source
High Average-Utility Itemset Sampling Under Length Constraints
, 2022 International audienceHigh Utility Itemset extraction algorithms are methods for discovering knowledge in a database where the items are weighted. Their usefulness has been widely demonstrated in many real world applications.
Diop, Lamine
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
An Incremental High-Utility Mining Algorithm with Transaction Insertion
The Scientific World Journal, 2015 Association-rule mining is commonly used to discover useful and meaningful patterns from a very large database. It only considers the occurrence frequencies of items to reveal the relationships among itemsets.
Jerry Chun-Wei Lin +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Efficient Mining of Frequent High Average-Utility Occupancy Sequences
Frequent High Utility Occupancy Sequence Mining (FHUOSM), which integrates both frequency and utility occupancy, has recently has become a key research focus with broad real-world applicability.
Dương, Văn Hải +4 more
core +1 more source
, 2021 Extracting a group of features together instead of a single feature from the mined opinions, such as “{battery, camera, design} of a smartphone,” may yield higher profit to the manufactures and higher customer satisfaction, and these can be called High ...
Motwani, Priyanka
core
Maintenance of discovered high average-utility itemsets in dynamic databases [PDF]
, 2018 High-utility itemset mining (HUIM) is an extension of traditional frequent itemset mining, which considers both quantities and unit profits of items in a database to reveal highly profitable itemsets regardless of their size. High average-utility itemset
Zhang, Binbin +10 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source