Results 111 to 120 of about 1,227,725 (294)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Improved adaptive-phase fuzzy high utility pattern mining algorithm based on tree-list structure for intelligent decision systems

Scientific Reports
With the rapid development of AI and big data mining technologies, computerized medical decision-making has become increasingly prominent. The aim of high-utility pattern mining (HUPM) is to discover meaningful patterns in medical databases that ...
Jing Chen, Aijun Liu, Hongjun Zhang, Shengyi Yang, Hui Zheng, Ning Zhou, Peng Li   +6 more
doaj   +1 more source

Incremental Top-k High Utility Pattern Mining and Analyzing Over the Entire Accumulated Dynamic Database

IEEE Access
Top-k high utility pattern mining, which extracts the highest top-k patterns that the users want to find, has been actively studied. Most previous studies in this domain have focused on static databases, where data insertions do not occur.
Chanhee Lee, Hanju Kim, Myungha Cho, Hyeonmo Kim, Bay Vo, Jerry Chun-Wei Lin, Philippe Fournier-Viger, Unil Yun   +7 more
doaj   +1 more source

Can genetic algorithms explain experimental anomalies? An application to common property resources [PDF]

It is common to find in experimental data persistent oscillations in the aggregate outcomes and high levels of heterogeneity in individual behavior. Furthermore, it is not unusual to find significant deviations from aggregate Nash equilibrium predictions.
Marco Casari
core  

Small-World File-Sharing Communities [PDF]

, 2003
Web caches, content distribution networks, peer-to-peer file sharing networks, distributed file systems, and data grids all have in common that they involve a community of users who generate requests for shared data.
Foster, Ian, Iamnitchi, Adriana, Ripeanu, Matei   +2 more
core   +4 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Potential and Spatial Structure of Population [PDF]

The goal of this work is to suggest a mechanism explaining different spatial patterns of residential locations. The basic idea is counterbalance of centripetal and centrifugal forces. This paper complements the previous author's works in this area.
Yuri Yegorov
core