Results 121 to 130 of about 1,895,501 (280)

An Inverted-File-based Algorithm for Efficient Mining High Utility Patterns

, 2016
Recently, mining high utility patterns has a huge range of applications such as retail market analysis and stock market prediction. The high utility pattern mining is an important research domain in data mining due to its capable of considering the ...
Tang, Hsiu-Pei
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Frequent Closed High-Utility Itemset Mining Algorithm Based on Leiden Community Detection and Compact Genetic Algorithm

IEEE Access
Traditional pattern mining algorithms are based on tree and linked list structures. However, they often only consider a single factor of frequency or utility and have to deal with exponential search spaces as well as generate numerous candidates.
Xiumei Zhao, Xincheng Zhong, Bing Han
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

IPHM: Incremental periodic high-utility mining algorithm in dynamic and evolving data environments

Heliyon
Periodic high-utility itemset (PHUI) mining can extend beyond the conventional approach of high-utility itemset mining by uncovering recurring customer purchase behaviors common in real-life scenarios (e.g., buying apples and oranges every three days or ...
Huiwu Huang, Shixi Chen, Jiahui Chen
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Subset-Lattice Algorithm for Mining High Utility Patterns over the Data Stream Sliding Window

, 2017
For the real world, high utility pattern mining over data streams is an important issue in the data mining field such as the supermarket. The traditional association rule mining only considers the present or absent of each item in the binary form and ...
Chen, Rong-Fu
core  

An Efficient UBLN-Tree based Algorithm for Mining High Average Utility Patterns in the Incremental Databases

, 2022
High Utility Pattern Mining (HUPM) considers the quantity and the profit of patterns. If the utility of the pattern is higher than or equal to a given threshold value, the pattern is a High Utility Pattern (HUP).
Yang, Yu-Zhen
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source