Results 101 to 110 of about 15,811,185 (295)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

An intelligent optimization method for communication monitoring alarm threshold based on BeiDou satellite positioning data

Discover Computing
This paper proposes an intelligent optimization method for BeiDou communication monitoring alarm thresholds based on Representation Learning and Adaptive Thresholding for Anomaly Detection (RLAT-AD), aiming to address the issue that under complex ...
An Lu, Yue Long, Fan JiFeng, Liang FaLiang, Li ZhongWei, Liu ZhiWei   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modeling and Simulation on the Hybrid Solution of Static Var Generator and Synchronous Condenser for Unlocking Power Output Limitation of Wind Farms Integrated into Weak Grid

Energies
The issues of low inertia, overvoltage, and wide-frequency oscillations in high-proportion renewable energy systems have become prominent, posing major challenges to renewable energy integration and threatening grid stability.
Haiyang Liang, Yanbin Zhang, Shuran Liu, Jianling Wu, Jifeng Fan, Yi Zhang, Junjie Yu, Tianlong Zhang, Ziyi Zhu   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Two-Sheath Loop Short Circuit Defects Detection in High-Voltage Cable Systems Using Sheath Current Phasors

The joint is the weak point of HV (high voltage) cable insulation systems; creep discharge between insulation layers of the cable joint, due to moisture intrusion, is one of the main defects leading to single-phase grounding.
Minghong Jiang, Zhanran Xia, Xinyun Gao, Jianfeng He, Bo Li, Bin Yang, Weihua Yuan, Yongheng Ai, Ruoxin Song, Hang Wang, Jing Tu   +10 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Research on Fault Identification of Hybrid Multi-Feed High-Voltage Direct Current System Based on Line Commutated Converter and Voltage Source Converter

With the rapid development of voltage source converter (VSC) and line commutated converter (LCC) technology and the relative concentration of power and load, the inverter station of the flexible DC system is fed into the same AC bus with the conventional
Xingyang Hu, Kun Chen, Long’en Zhang, Hengxuan Li, Pangqi Ye, Ting Wang   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source