Results 111 to 120 of about 877,581 (317)
Discover Artificial IntelligenceIn the era of rapid development of digitalization and science and technology, infrared images are widely used in security, industry and other fields, but their target recognition and positioning face many difficulties. The existing image segmentation and
Runming He +3 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Voltage sags in power distribution networks
, 2005 Voltage sags have become increasingly important when considering the various power quality issues that cause inconvenience to customers. For some customers voltage sags cause especially high costs. Thus, power distribution companies should understand the
Heine, Pirjo
core
Improving high voltage power system performance using arc suppression coils [PDF]
, 2011 Arc suppression coils provide a low cost method of increasing both the reliability and safety of high voltage transmission and distribution systems. Although the concept is not new, the advent of modern control equipment allows fresh opportunities for ...
Burgess, Robert Thomas
core
Modelling And Analysis Of A MEMS Approach To DC Voltage Step Up Conversion
, 2003 This paper studies the principle of a voltage step-up converter based on a micromachined variable parallel-plate capacitor in combination with an electrostatic actuator.
Haas, C. H. +5 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
This study examines and compares the breakdown and aging properties of five insulating liquids. Additionally, the influence of different voltage polarities on these properties was analyzed to investigate the effect of aging on polarity behavior under ...
Ronald Plath, Sabrina Krügel
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source