Results 101 to 110 of about 1,684,904 (300)

Foldscope: origami-based paper microscope.

open access: yesPLoS ONE, 2014
Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume
James S Cybulski   +2 more
doaj   +1 more source

Gamma rays from giant molecular clouds [PDF]

open access: yes
Giant Molecular Clouds (GMCs) are massive, bounded, cool, dense regions containing mostly H2, but also H I, CO, and other molecules. These clouds occupy less than 1 percent of the galactic volume, but are a substantial part of the interstellar mass. They
Hunter, Stanley D., Kanbach, Gottfried
core   +1 more source

Miniaturized high-frequency sine wave gating InGaAs/InP single-photon detector

open access: yes, 2018
High-frequency gating InGaAs/InP single-photon detectors (SPDs) are widely used for applications requiring single-photon detection in the near-infrared region such as quantum key distribution.
Chen, Wei   +9 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Advances in atmospheric temperature profile measurements using high spectral resolution lidar

open access: yesEPJ Web of Conferences, 2018
This paper reports the atmospheric temperature profile measurements using a University of Wisconsin-Madison High Spectral Resolution Lidar (HSRL) and describes improvements in the instrument performance.
Razenkov Ilya I., Eloranta Edwin W.
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Learning-by-Doing in a High-Skill Profession when Stakes are High: Evidence from Advanced Cancer Surgery [PDF]

open access: yes, 2014
Although learning-by-doing is believed to be an important source of productivity growth there is limited evidence that production volume affects productivity in a causal sense.
Avdic, Daniel   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Optical Computed-Tomographic Microscope for Three-Dimensional Quantitative Histology

open access: yesCellular Oncology, 2004
A novel optical computed‐tomographic microscope has been developed allowing quantitative three‐dimensional (3D) imaging and analysis of fixed pathological material.
Ravil Chamgoulov   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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