Results 71 to 80 of about 1,684,904 (300)

A Technique for Narrowband Time Series Photometry: the X-ray Star V2116 Oph [PDF]

, 1998
We have used innovative features of the Taurus Tunable Filter instrument on the 3.9-m Anglo-Australian Telescope to obtain nearly-continuous, high-throughput, linear photometry of V2116 Oph in a 7 Angstrom bandpass at the center of the O I 8446 emission ...
Bland-Hawthorn J., Bruce  Margon, Eric W.  Deutsch, Glass I. S., Greenhill J. G., Jablonski F., Joss  Bland‐Hawthorn, Laurent P.   +7 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Infrared Imaging Spectrograph (IRIS) for TMT: Volume phase holographic grating performance testing and discussion [PDF]

, 2014
Maximizing the grating efficiency is a key goal for the first light instrument IRIS (Infrared Imaging Spectrograph) currently being designed to sample the diffraction limit of the TMT (Thirty Meter Telescope). Volume Phase Holographic (VPH) gratings have
Chen, Shaojie, Larkin, James E., Maire, Jerome, Meyer, Elliot, Mieda, Etsuko, Moore, Anna M., Simard, Luc, Wright, Shelley A.   +7 more
core   +2 more sources

Self-heating probe instrument and method for measuring high temperature melting volume change rate of material

Chinese Journal of Mechanical Engineering, 2013
The castings defects are affected by the melting volume change rate of material. The change rate has an important effect on running safety of the high temperature thermal storage chamber, too. But the characteristics of existing measuring installations are complex structure, troublesome operation and low precision.
Junwei Wang, Zhiping Wang, Yang Lu, Bo Cheng   +3 more
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

An instrument for the rapid quantification of PM-bound ROS: the Particle Into Nitroxide Quencher (PINQ) [PDF]

Atmospheric Measurement Techniques, 2019
Reactive oxygen species (ROS) present on or generated by particulate matter (PM) have been implicated in PM-induced health effects. Methodologies to quantify ROS concentrations vary widely, both in detection and collection methods.
R. A. Brown, S. Stevanovic, S. Stevanovic, S. Bottle, Z. D. Ristovski, Z. D. Ristovski   +5 more
doaj   +1 more source

IceCube: physics, status, and future

, 2010
The IceCube observatory is the first cubic kilometre scale instrument in the field of high-energy neutrino astronomy and cosmic rays. In 2009, following five successful deployment seasons, IceCube consisted of 59 strings of optical modules in the South ...
Abbasi, Abbasi, Abbasi, Abbasi, Abbasi, Abbasi, Abdo, Achterberg, Achterberg, Achterberg, Ackermann, Amenomori, Andrés, Andrés, Bertone, Besson, Bramall, Braun, Cowen, Dunkley, Engel, Gondolo, Greisen, Hooper, Jungman, Klas Hultqvist, Klein, Landau, Landsman, Mena, Migdal, Mücke, Price, Razzaque, Silk, Stecker, Vandenbroucke, Waxman, Waxman, Wikström, Zatsepin   +40 more
core   +1 more source

The HARPS search for southern extra-solar planets. IX. Exoplanets orbiting HD 100777, HD 190647, and HD 221287 [PDF]

, 2007
The HARPS high-resolution high-accuracy spectrograph is offered to the astronomical community since the second half of 2003. Since then, we have been using this instrument for monitoring radial velocities of a large sample of Solar-type stars (~1400 ...
Benz, Willy, Bouchy, Francois, Curto, Gaspare Lo, Lovis, Christophe, Mayor, Michel, Moutou, Claire, Naef, Dominique, Pepe, Francesco, Queloz, Didier, Santos, Nuno C., Udry, Stephane   +10 more
core   +5 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Implementation of Vibrancy Awaking Pressure Measuring Instrument for Single Hydraulic Prop

Journal of Measurement Science and Instrumentation, 2011
An instrument awakened by means of vibration for single hydraulic prop pressure measuring is described in this paper.The principle and implementation of this method are introduced in detail.The instrument uses the high-performance single chip C8051F310 ...
Feng-long ZHENG, Li-ling WANG, Kai ZHU, Yang CHEN, Wen-jing YAO   +4 more
doaj