Results 51 to 60 of about 109,071 (235)

Higher-order parabolic equations without conditions at infinity

open access: yesJournal of Mathematical Analysis and Applications, 2002
This paper is devoted to the following Cauchy problem: \[ \begin{cases} \rho\frac {\partial u}{\partial t}=\sum^m_{k=0}(-1)^{k+1} \frac {\partial^k}{\partial x^k} \left(a_k\frac {\partial^ku}{\partial x^k} \right)- c_0| u|^{p-1}u\quad &\text{in }S=\mathbb{R}\times(0,T)\\ u=u_0\quad &\text{in }\mathbb{R}\times \{0\},\end{cases}\tag{1} \] where \(p>1\), \
MARCHI, CLAUDIO, TESEI A.
openaire   +2 more sources

Higher order conditioning of a taste aversion [PDF]

open access: yesAnimal Learning & Behavior, 1975
Two groups of rats each received 5 drops of NaCl solution from a dropper placed directly inside the mouth. The experimental group was then injected with lithium chloride to establish a conditioned taste aversion. The control group was injected 24 h later. After a recovery day the above procedures were repeated.
Nigel Bond, Wayne Harland
openaire   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

A logic with higher order conditional probabilities [PDF]

open access: yesPublications de l'Institut Mathematique, 2007
We investigate probability logic with the conditional probability operators This logic, denoted LCP, allows making statements such as: P?s?, CP?s(? | ?) CP?0(? | ?) with the intended meaning "the probability of ? is at least s" "the conditional probability of ? given ? is at least s", "the conditional probability of ? given ? at most 0".
Zoran Ognjanovic, Nebojsa Ikodinovic
openaire   +2 more sources

Higher-order conditioning: A critical review and computational model.

open access: yesPsychological Review, 2022
Higher-order conditioning results from a simple training procedure: Pairing two relatively neutral conditioned stimuli, A and X, allows properties separately conditioned to X (e.g., through pairing it with an unconditioned stimulus, US) to be evident during A.
Robert C. Honey, Dominic M. Dwyer
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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