Results 111 to 120 of about 3,450,969 (293)
Addition of higher order plate and shell elements into NASTRAN computer program [PDF]
Two higher order plate elements, the linear strain triangular membrane element and the quintic bending element, along with a shallow shell element, suitable for inclusion into the NASTRAN (NASA Structural Analysis) program are described. Additions to the
Goglia, G. L., Narayanaswami, R.
core +1 more source
Embedded discontinuities for softening solids [PDF]
, 1999 Additional, discontinuous functions are added to the displacement field of standard finite elements in order to capture highly localised zones of intense straining.
Sluys, LJ, Wells, GN
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
An efficient C0 FE model for the analysis of composites and sandwich laminates with general layup
Latin American Journal of Solids and StructuresA C0 continuous finite element model is developed to model the refined higher order shear deformation theory. The proposed element is an upgraded version of an element based on higher order shear deformation theory.
S.K. Singh +3 more
doaj +1 more source
Steerable Higher Order Mode Dielectric Resonator Antenna With Parasitic Elements for 5G Applications
IEEE Access, 2017 This paper presents the findings of a steerable higher order mode (TE1δ3y) dielectric resonator antenna with parasitic elements. The beam steering was successfully achieved by switching the termination capacitor on the parasitic element.
Nor Hidayu Shahadan +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Trace Finite Element Methods for PDEs on Surfaces
, 2016 In this paper we consider a class of unfitted finite element methods for discretization of partial differential equations on surfaces. In this class of methods known as the Trace Finite Element Method (TraceFEM), restrictions or traces of background ...
Olshanskii, Maxim A., Reusken, Arnold
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source