Results 61 to 70 of about 17,871,941 (289)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
In Search for the Super Element: Algorithms to Generate Higher Order Elements
International Journal of Trend in Scientific Research and Development, 2018 This work was motivated by the need that may arise during the creation of finite element programs, for higher order elements. The problem of selecting or creating shape functions that satisfy the required need of the problem may be one major problem that stand in the way of the element creation.
openaire +2 more sources
Visualization of higher order finite elements. [PDF]
, 2004 Finite element meshes are used to approximate the solution to some differential equation when no exact solution exists. A finite element mesh consists of many small (but finite, not infinitesimal or differential) regions of space that partition the problem domain, {Omega}.
Thompson, David C. +3 more
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Higher order Perturbation Stochastic Finite Element Method of the Linear elastic Structure
工程科学与技术, 2014 :Computational precision and error control are very important to the numerical computation of the stochastic finite element method.Based on theory of random fields and perturbation finite element method,computational formulas of expected values and nth ...
廖光明, 陈兵, 王遂泸
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Hybrid volume completion with higher-order Bézier elements [PDF]
Computer Aided Geometric Design, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Suqin Zeng, Elaine Cohen
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Shock and Vibration, 2008 The spectral element matrix is derived for a straight and uniform beam element having an arbitrary cross-section. The general higher-order beam theory is used, which accurately accounts for the transverse shear deformation out of the cross-sectional ...
Jiao Sujuan +3 more
doaj +1 more source