Results 71 to 80 of about 17,871,941 (289)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Higher Order mz-elements in Coherent Quantales

Scientific Annals of Computer Science
The mz-elements of a coherent quantale have recently been de- fined by the author as an abstraction of the mz-ideals of a unital commutative ring. Having as its starting point the Dube and Ighedo recent paper on higher order ideals in ring theory, this paper deals with the higher order mz-elements of a coherent quantale A. For each natural number n we
openaire   +4 more sources

Development of Higher Order Stiffened Shell Element (HOST9) for the Static Analysis of Stiffened Laminated Plates

Civil and Environmental Engineering
A new higher order stiffened shell element (HOST9) is developed comprising of a 9 noded flat shell element and a 3 noded stiffener element for analysis of stiffened laminated plates. The shell element is a lagrangian element.
Sheth Karan, Joshi Rajendra
doaj   +1 more source

Nonlinear Dynamics Analysis of FGM Shell Structures with a Higher Order Shear Strain Enhanced Solid-Shell Element

Latin American Journal of Solids and Structures
In this paper, non-linear dynamics analysis of functionally graded material (FGM) shell structures is investigated using the higher order solid-shell element based on the Enhanced Assumed Strain (EAS).
A. Hajlaoui, E. Triki, A. Frikha, M. Wali, F. Dammak   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Higher-order + Polymorphic = Reusable [PDF]

This paper explores how certain ideas in object oriented languages have their correspondents in functional languages. In particular we look at the analogue of the iterators of the C++ standard template library.
Thompson, Simon
core   +1 more source

Acoustic displacement triangle based on the individual element test

Latin American Journal of Solids and Structures
A three node -displacement based- acoustic element is developed. In order to avoid spurious rotational modes, a higher order stiffness is introduced. This higher order stiffness is developed from an incompatible strain field which computes element volume
S. Correa, C. Militello, M. Recuero
doaj   +1 more source