Results 81 to 90 of about 66,503 (311)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The scale dependence of perturbative QCD predictions for e+e− event shape moments and LHC observables [PDF]

, 2013
Perturbative QCD predictions that are truncated at fixed order have an unphysical dependence on the renormalisation procedure. We investigate two methods of avoiding scale and scheme dependence in QCD predictions of physical observables: the Effective ...
MORGAN, KATHARINE,ELIZABETH
core  

Estimation of uncertainties from missing higher orders in perturbative calculations

, 2015
In this proceeding we present the results of our recent study (hep-ph/1409.5036) of the statistical performances of two different approaches, Scale Variation (SV) and the Bayesian model of Cacciari and Houdeau (CH)(hep-ph/1105.5152) (which we also extend to observables with initial state hadrons), to the estimation of Missing Higher-Order Uncertainties
openaire   +4 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Heavy quark fragmentation in e + e − collisions to NNLO+NNLL accuracy in perturbative QCD

Journal of High Energy Physics
Fragmentation of heavy quarks into heavy-flavoured hadrons receives both perturbative and non-perturbative contributions. We consider perturbative QCD corrections to heavy quark production in e + e − collisions to next-to-next-to-leading order accuracy ...
Leonardo Bonino, Matteo Cacciari, Giovanni Stagnitto   +2 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Two loop vertices and tree level multicollinear limits in QCD [PDF]

, 2005
We present a summary of the methods required to solve loop-integrals and their reduction to Master Integrals. We then present the expansion in d = 4 - 2e of the Master Integrals required for the two loop massless vertex diagrams with three off-shell legs.
Birthwright, Thomas G., Birthwright, Thomas G, Thomas G. Birthwright   +2 more
core  

Applications of the perturbative gradient flow at higher orders in quantum chromodynamics

, 2021
The gradient flow formalism introduced ten years ago proved to be a useful tool for lattice simulations of Quantum Chromodynamics. Its flagship applications are new strategies to set the scale of these simulations.
Lange, Fabian
core   +1 more source

Perturbative computations of neutron-proton scattering observables using renormalization-group invariant chiral effective field theory up to N3LO [PDF]

Physical Review C
We predict neutron-proton scattering cross sections and polarization observables up to next-to-next-to-next-to-leading order in a renormalization-group invariant description of the strong nucleon-nucleon interaction.
Oliver Thim, Andreas Ekström, C. Forss'en   +2 more
semanticscholar   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source