Results 51 to 60 of about 6,302,443 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Éclairer les mathématiques par les exemples ?

Recherches en Éducation, 2016
The strong link between mathematics and examples is analysed as a very component of mathematical activity. Then some didactical tentative proposals are presented for developing mathematical training based on a reasoned use of examples.
Alain Kuzniak, Marc Rogalski, Laurent Vivier   +2 more
doaj   +1 more source

Offshore education : offshore education in the wider context of internationalisation and ICT: experiences and examples from Dutch higher education [PDF]

, 2007
This report presents a study on offshore education conducted by a consortium of Dutch higher education researchers and commissioned by the Digital University (DU). The study explored the extent to which Dutch higher education institutions are involved in
Adrichem, Nelleke van, Deen, Jarno, Dekker, Peter, Mesker, Peter, Verkroost, Marie-Jose, Vossensteyn, Hans, Weert, Egbert de   +6 more
core   +2 more sources

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Un état des lieux des recherches sur les espaces d’apprentissage universitaires

Recherches en Éducation
University learning spaces are at the heart of political issues that can be analyzed in terms of their production and use. The term "space" is used in a variety of ways, depending on the disciplines to which the authors refer, and is rarely considered in
Jean-François Thémines, Claire Saint Martin (de)   +1 more
doaj   +1 more source

L’étude de cas face à l’exemple : pratiques et enjeux dans l’enseignement de la géographie et de l’aménagement à l’université

Recherches en Éducation, 2016
Geography and Urban planning teaching is focused on space in a general and theoretical point of view but it also deals with specific places. Using examples or case studies to teach geography or urban planning seems to be natural.
Caroline Leininger-Frézal, Nicolas Douay, Marianne Cohen   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Les transitions énonciatives dans un atelier d’écriture scientifique, de la visibilité orale à l’effacement scriptural

Recherches en Éducation
This article questions the epistemic issues and pragmatic contributions of a scientific writing workshop, exploring more specifically the enunciative aspects of the productions that emerge from it.
Florence Vanderpoorten
doaj   +1 more source

Fees and loathing: higher education finance and university participation [PDF]

With the UK's cap on tuition fees due to rise to £9,000, Gill Wyness looks at the impact of past fee increases on young people's decisions to go to university.wage differentials, returns to ...
Gill Wyness
core