Results 51 to 60 of about 2,685,365 (305)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

L’étude de cas face à l’exemple : pratiques et enjeux dans l’enseignement de la géographie et de l’aménagement à l’université

Recherches en Éducation, 2016
Geography and Urban planning teaching is focused on space in a general and theoretical point of view but it also deals with specific places. Using examples or case studies to teach geography or urban planning seems to be natural.
Caroline Leininger-Frézal, Nicolas Douay, Marianne Cohen   +2 more
doaj   +1 more source

Competitiveness in Higher Education: The Case of University Management [PDF]

Journal of Competitiveness, 2019
As a response to current global trends in the field of higher education and studies, the attitude has become prevalent in the European Commission and among member states of the European Union (EU) that major reforms are required to help European higher education successfully compete under the conditions of globalization and a knowledge-based economy ...
Bilevičiūtė, Eglė, Drakšas, Romualdas, Nevera, Andrius, Vainiutė, Milda   +3 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Les transitions énonciatives dans un atelier d’écriture scientifique, de la visibilité orale à l’effacement scriptural

Recherches en Éducation
This article questions the epistemic issues and pragmatic contributions of a scientific writing workshop, exploring more specifically the enunciative aspects of the productions that emerge from it.
Florence Vanderpoorten
doaj   +1 more source

L’usage des exemples dans l’enseignement de la physique à l’université : un marqueur de l’identité pédagogique des enseignants-chercheurs ?

Recherches en Éducation, 2016
Using examples in physics teaching at university level is commonplace and inevitable. As researchers in physics education (didactic of physics) we question what academics in physics say when they describe why, when and how they use examples while they ...
Cécile de Hosson, Nicolas Décamp, Philippe Colin   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Conceptions et usages de l’exemple dans l’enseignement de l’histoire à l’université. Foisonnement, tensions, décalages et paradoxes

Recherches en Éducation, 2016
What is an example to academic teachers in history and what for? What value is placed on the example and how is it used in teaching history at the University? What relationship between uses of example and nature of history?
Anne Emmanuelle Demartini
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source