Results 81 to 90 of about 15,964,509 (348)

Psychosocial Burden Among Informal Caregivers of Adult Cancer Patients Attending a Tertiary Care Cancer Center in Coastal South India

SAGE Open, 2019
Cancer is the most dreaded and chronic disease with its treatment lasting almost lifelong with an uncertainty of cure. This not only adversely affects the quality of life among patients but also poses a psychosocial burden among family members ...
Bhaskaran Unnikrishnan, Priya Rathi, P. U. Prakash Saxena, Apoorva Aggarwal, Shashank Shekhar, Sarthak Bansal, B. Venkat Naidu, Sarath Menon   +7 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Clinical Evaluation of Kinesio Taping Outcomes in Stage II Cellulite: A Pilot Study

Reabilitacijos Mokslai: Slauga, Kineziterapija, Ergoterapija
Background. Cellulite is a common aesthetic condition linked to alterations in subcutaneous fat and dermal connective tissue, with possible impairment of microcirculation and lymphatic drainage. Kinesio taping (KT) is used in physiotherapy, but evidence
Laura Žalienė, Mercedes Šulcaitė-Vasiljeva, Simona Kasperavičiūtė, Jurgita Boltutienė, Simona Urbonienė, Daiva Stančaitytė , Gražina Šniepienė, Vitalija Gerikienė   +7 more
doaj   +1 more source

Results of implementation of social rehabilitation technologies for people with lower extremity diseases/injuries

Social Welfare: Interdisciplinary Approach, 2013
People with lower extremity diseases/injuries have limited mobility that affects their participation in socio-economic processes, including integration into the labour market. It is one of the risk groups that are exposed to the risk of social exclusion,
Svetlana Usca, Velta Lubkina, Aivars Kaupuzs, Lorita Rizakova   +3 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Higher education [PDF]

British Dental Journal, 2000
J, Renshaw, R, Bedi
openaire   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of carbon black from Ageratina adenophora and various other carbon anode plate additives on the performance of lead acid batteries

Chimica Techno Acta
The incorporation of carbon materials in batteries serves to enhance its performance by improving conductivity, achieving uniform active material distribution, increasing capacity, mitigating sulfation, extending cycle life, and considering potential ...
Subban Ravi, Baskaran Vignesh, Nagarajan Meimoorthy, Bharathamani Dhanus Kumar, Lakshmanan Sathishkumar, Nagarajan Mohankumar, Nagarajan Kannapiran   +6 more
doaj   +1 more source

Nutrition education: higher education [PDF]

Proceedings of the Nutrition Society, 1976
M E, Lonergan, D A, Parry
openaire   +2 more sources