Results 111 to 120 of about 2,323,053 (317)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

αB-crystallin enhances radioresistance in basal-like breast cancer cells by suppressing caspase-3 activation

Science Progress
Objective For most patients with breast cancer undergoing breast-conserving surgery, radiotherapy reduces local recurrence and mortality. However, in basal-like breast cancer, radiotherapy is less effective due to the cells’ intrinsic radioresistance ...
Yan Yuan, Xubaihe Zhang, Ying Xu, Yangyang Ge, Anqing Wu   +4 more
doaj   +1 more source

Marketing Approach in the Management of Higher Education Institutions [PDF]

The purpose of this paper is to present relevant aspects of the marketing approach of the universities’ activities in the current market conditions of higher education institutions.
Amalia PANDELICÃ, Mihaela DIACONU
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

E-Learning Strategies in Developing Research Performance Efficiency: Higher Education Institutions [PDF]

, 2019
The study aimed to identify E- Learning strategies and their relation to the efficiency of research performance in foreign and Palestinian universities (University of Ottawa, Munster, Suez Canal, Al-Azhar, Islamic, Al-Aqsa).
Abdalmenem, Samia A. M., Amuna, Youssef M. Abu, Arqawi, Samer M., Naser, Samy S. Abu, Shobaki, Mazen J. Al   +4 more
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

High-sensitivity qPCR detection method based on silver flower-like LSPR-active material

Scientific Reports
Quantitative polymerase chain reaction (qPCR) technology offers advantages such as easy operation and high specificity, but also faces issues like lengthy detection time and low sensitivity.
Congxi Song, Keliang Li, Zhihui Jiang, Yibo Tang, Wusheng Hu, Hongmin Mao, Xin Zhao, Jian Yin, Huanjun Lu, Zhaoliang Cao   +9 more
doaj   +1 more source

Educational Management in Higher Education Institutions:

Cadernos de Educação Tecnologia e Sociedade
Adequate quality and competitiveness management strategies in universities and other higher education institutions require a balanced approach to educational management. It involves setting clear goals and objectives, developing a system for monitoring and evaluating the quality of teaching and research activities, and continuously improving the ...
Illia Lysokon, Tamara Vasyliuk, Yuliia Barulina, Ivanna Razmolodchykova, Hanna Zakharova   +4 more
openaire   +1 more source

Analysis of Education Problems at Higher Education Institutions

Verslas: teorija ir praktika, 2006
The Bologna declaration stresses the importance of education and educational co-operation in the development and strengthening of stable, peaceful and democratic societies. Additionally the declaration highlights the need to promote European co-operation in quality assurance with a view to develop comparable criteria and methodologies.
openaire   +4 more sources