Results 61 to 70 of about 15,910,979 (247)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

State of higher education minority report a status report and recommendations for the Higher Education Funding Study Council

, 2006
Title from cover of PDF document (viewed July 5, 2006).; "May 31, 2006."; Harvested from the web on 7/6/06[Sections]: Perspective on the current status of higher education in Ohio -- Findings of the Higher Education Funding Study Council -- Findings of ...
Ohio. Higher Education Funding Study Council., Zurz, Kimberly.   +1 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Floristic Analysis of Vascular Plants in the Ziwuling Mountains, Shaanxi Province

Plants
A study was conducted on the vascular floras of the Ziwuling Mountains in Shaanxi Province to establish a foundational database, providing data support for the conservation and utilization of the Ziwuling Mountains’ plant diversity resources.
Shuyue Ma, Fangfang Qiang, Guangquan Liu, Changhai Liu, Chongyan Bai, Ning Ai   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Research progress in low-temperature solders for electronic packaging

Cailiao gongcheng
The combination of multiple temperature gradients in interconnect solders is key to achieving high-density chip integration. Low-temperature solder alloys are the premise for implementing low-temperature processes and the guarantee for high reliability ...
LI Fangliang, GAN Guisheng, DOU Junfeng, XIE Daochun, ZHU Junxiong, GENG Mingli, HAN Jun, YANG Donghua, PAN Hao, XIA Daquan, XU Xiangtao   +10 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Quality of Economics Education in Bulgarian Higher Education Institutions: Аssessment Criteria Systematization

Проблеми на постмодерността
Education is a key factor for national competitiveness and a significant element of the social infrastructure, on which the achieved level of public welfare depends.
Maya Tsoklinova
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Costs and efficiency of higher education institutions in England: a DEA analysis [PDF]

, 2011
As student numbers in higher education in the UK have expanded during recent years, it has become increasingly important to understand its cost structure.
Johnes, J., Thanassoulis, E., Kortelainen, Mika, Johnes, Jill, Kortelainen, M., Johnes, G., Thanassoulis, Emmanuel, Johnes, Geraint, G Johnes, J Johnes, E Thanassoulis, M Kortelainen   +11 more
core   +1 more source