Results 61 to 70 of about 2,323,053 (317)

The impact of asymmetrical gene expression on the development of spike morphology in Triticum aestivum

iMetaOmics
Wheat yield is primarily determined by panicle density per unit area, grain count per spike, and grain weight. The proliferation of wheat spikes affects both the number of grains per spike and grain weight. However, the molecular regulatory mechanisms of
Fang He, Xiaojuan Liu, Qian Ma, Wei Wan, Luhua Li, Kuiyin Li, Zhenzhen Jia, Suqin Zhang, Ruhong Xu, Mingjian Ren   +9 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Towards to a modern higher education institutions in Poland [PDF]

, 2017
Since the dawn of time, universities have contributed significantly to the economic development. However, presently operating higher education institutions are characterized by a significant diversity of goals, missions and functions ...
Deren, A. M., Skonieczny, J.
core   +1 more source

Higher education provision for students with disabilities in Cyprus [PDF]

, 2007
Internationally, the number of students with disabilities entering higher education institutions is on the rise. Research estimates that 8–10% of students attending higher education are registered with disability, with learning difficulties being the ...
Hadjikakou, Kika, Hartas, Dimitra
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Research progress in low-temperature solders for electronic packaging

Cailiao gongcheng
The combination of multiple temperature gradients in interconnect solders is key to achieving high-density chip integration. Low-temperature solder alloys are the premise for implementing low-temperature processes and the guarantee for high reliability ...
LI Fangliang, GAN Guisheng, DOU Junfeng, XIE Daochun, ZHU Junxiong, GENG Mingli, HAN Jun, YANG Donghua, PAN Hao, XIA Daquan, XU Xiangtao   +10 more
doaj   +1 more source

Higher Education Systems and Institutions, Angola

, 2020
The Republic of Angola is located in the southwest coast of Africa, bordered by the Democratic Republic of Congo to the north, Zambia to the east, and Namibia to the south. With an area of about 1,246,700 square km and a population of 30 million, it is the largest Portuguese-speaking country in Africa.
Videira, P., Teixeira, P.
openaire   +2 more sources

Austrian higher education institutions' idiosyncrasies and technology transfer system [PDF]

, 2008
The aim of this paper is to present the findings of a PhD research (Heinzl, 2007) conducted on the Universities of Applied Sciences in Austria. The research is to establish an idiosyncrasy model for Universities of Applied Sciences in Austria showing the
Heinzl, J, Kaufmann, HR, Kor, AL, Orange, G   +3 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source