Results 81 to 90 of about 15,910,979 (247)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Report of the Task Force to Examine the Impact of the Proposed Regulations on Students and Campus Safety at Institutions of Higher Education in the State

, 2020
1 online resource (30 unnumbered pages)"Submitted to the Higher Education and Employment Advancement Committee."; "November 4, 2020.
Connecticut. General Assembly. Higher Education & Employment Advancement Committee. Task Force to Examine the Impact of the Proposed Regulations on Students and Campus Safety at Institutions of Higher Education in the State, author
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Whole-genome analysis reveals the growth-promoting and biocontrol potential of Bacillus amyloliquefaciens Ba. YN.J3 isolated from Avena Sativa

BMC Genomics
Background Endophytic bacteria serve as important resources for the development of novel biocontrol agents for sustainable agriculture. This study provides a detailed characterization of a newly isolated oat endophyte, Bacillus amyloliquefaciens Ba.
Wei Quan, Cheng-Zhong Zheng, Muhammad Ayaz, Hui Chen, Chun-Yang Wang, Chen-Lu Liu, Zhi-Gang Liu, Bao-Zhu Dong, Hong-You Zhou   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Ergodicity Breaking and Ageing in a Vibrational Motor

Entropy
The ergodicity and ageing phenomena in a vibrational motor system driven by a periodic external force are investigated. Within the tailored parameter regime, the amplitude and frequency demonstrate contrasting effects on ergodicity.
Yaqin Yang, Hongda Shi, Luchun Du, Wei Guo   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Other title: Sharing courses/programs at Ohio's colleges and universities

, 2017
"September 2017."Background -- Research -- Framework -- Recommended steps to implementing an institutional course/program collaboration -- ConclusionOhio Revised Code Section 3333.90 requires the Ohio Department of Higher Education (ODHE) to establish a ...
Ohio. Department of Higher Education
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Spatial Distribution Characteristics and Driving Factors of Formicidae in Small Watersheds of Loess Hilly Regions

Insects
This study takes the Jinfoping Small Watershed in the Loess Hilly Region as the research area. Through field investigation and laboratory analysis, combined with methods such as spatial autocorrelation analysis, the ordinary least squares method (OLS ...
Yu Tian, Fangfang Qiang, Guangquan Liu, Changhai Liu, Ning Ai   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Financial statistics of institutions of higher education:

Report year ends June 30.Mode of access: Internet.Vols. for issued by the Center under its earlier form of name: National Center for Educational Statistics.Continued by the Center's Financial statistics of institutions of higher education: property ...
National Center for Education Statistics.
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