Results 91 to 100 of about 12,698,759 (344)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Вестник СибАДИIntroduction. As part of solving the urgent problem of forecasting technical impacts and residual life depending on operating time, a method for determining the effect of the starting mode on a change in the structural parameter determining reliability ...
N. A. Zagorodnii +2 more
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Existence of positive periodic solutions for higher order singular functional difference equations
Electronic Journal of Qualitative Theory of Differential Equations, 2014 We study a higher order singular functional difference equation on $\mathbb{Z}$. Sufficient conditions are obtained for the existence of at least one positive periodic solution of the equation.
Jacob Johnson +3 more
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
MathematicsNumerical methods are frequently developed to investigate concepts for approximately solving ordinary differential equations (ODEs). To achieve minimal error and higher accuracy in approximate solutions, researchers have focused on developing algorithms ...
Abdul Hadi Bhatti +5 more
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A Lyapunov type inequality for fractional operators with nonsingular Mittag-Leffler kernel
Journal of Inequalities and Applications, 2017 In this article, we extend fractional operators with nonsingular Mittag-Leffler kernels, a study initiated recently by Atangana and Baleanu, from order α ∈ [ 0 , 1 ] $\alpha\in[0,1]$ to higher arbitrary order and we formulate their correspondent integral
Thabet Abdeljawad
doaj +1 more source
, 2017 For the family of polynomials in one variable $P:=x^n+a_1x^{n-1}+\cdots +a_n$, $n\geq 4$, we consider its higher-order discriminant sets $\{ \tilde{D}_m=0\}$, where $\tilde{D}_m:=$Res$(P,P^{(m)})$, $m=2$, $\ldots$, $n-2$, and their projections in the ...
Kostov, Vladimir Petrov
core
Higher-order port-graph rewriting
, 2012 The biologically inspired framework of port-graphs has been successfully used to specify complex systems. It is the basis of the PORGY modelling tool. To facilitate the specification of proof normalisation procedures via graph rewriting, in this paper we
Fernández, Maribel, Maulat, Sébastien
core +2 more sources
CONFIGURATIONS OF HIGHER ORDERS
Advances and Applications in Discrete Mathematics, 2022 This paper begins by extending the notion of a combinatorial configuration of points and lines to a combinatorial configuration of points and planes that we refer to as configurations of order $2$. We then proceed to investigate a further extension to the notion of points and $k$-planes ($k$-dimensional hyperplanes) which we refer to as configurations ...
openaire +3 more sources
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source