Results 101 to 110 of about 4,523,229 (316)

Development of Higher Order Stiffened Shell Element (HOST9) for the Static Analysis of Stiffened Laminated Plates

Civil and Environmental Engineering
A new higher order stiffened shell element (HOST9) is developed comprising of a 9 noded flat shell element and a 3 noded stiffener element for analysis of stiffened laminated plates. The shell element is a lagrangian element.
Sheth Karan, Joshi Rajendra
doaj   +1 more source

Forced-Perturbed Fractional Differential Equations of Higher Order: Asymptotic Properties of Non-Oscillatory Solutions

Fractal and Fractional
This study investigates the asymptotic behavior of non-oscillatory solutions to forced-perturbed fractional differential equations with the Caputo fractional derivative.
Said R. Grace, Gokula N. Chhatria, S. Kaleeswari, Yousef Alnafisah, Osama Moaaz   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dynamic higher order expectations [PDF]

In models where privately informed agents interact, agents may need to form higher order expectations, i.e. expectations of other agents' expectations.
Kristoffer Nimark
core  

Pedagogical conservatism of university teachers [PDF]

Известия Саратовского университета. Новая серия: Акмеология образования. Психология развития
The relevance of the research is due to the need to implement the principle of cooperation and interaction of the subjects of the educational process, and to use the creative approach in the situation of modernizing higher education.
Avakyan, Inna B.
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Canonical Higher-Order Kernels for Density Derivative Estimation [PDF]

In this note we present r th order kernel density derivative estimators using canonical higher-order kernels. These canonical rescalings uncouple the choice of kernel and scale factor. This approach is useful for selection of the order of the kernel in a
Christopher F. Parmeter, Daniel J. Henderson   +1 more
core  

Pure higher-order effects in the portfolio choice model [PDF]

, 2016
This paper examines the effects of higher-order risk attitudes and statistical moments on the optimal allocation of risky assets within the standard portfolio choice model.
Paya, Ivan, Paya, I., Niguez, Trino-Manuel, Ivan Paya, Peel, David Alan, Trino-Manuel Ñíguez, Peel, D., Ñíguez, T.M., David Peel   +8 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source