Results 111 to 120 of about 12,698,759 (344)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Design LQR Controller for Higher Order Systems Based on the Reduction Model

Journal of Engineering and Sustainable Development, 2015
This paper present a simple method for reducing the linear higher order systems. The coefficient of the reduction model is obtained by using the modified dominant pole technique, while the coefficients of the numerator are obtained by reduced order ...
Noor Safaa Abdul-Jaleel
doaj  

Development of Higher Order Stiffened Shell Element (HOST9) for the Static Analysis of Stiffened Laminated Plates

Civil and Environmental Engineering
A new higher order stiffened shell element (HOST9) is developed comprising of a 9 noded flat shell element and a 3 noded stiffener element for analysis of stiffened laminated plates. The shell element is a lagrangian element.
Sheth Karan, Joshi Rajendra
doaj   +1 more source

Forced-Perturbed Fractional Differential Equations of Higher Order: Asymptotic Properties of Non-Oscillatory Solutions

Fractal and Fractional
This study investigates the asymptotic behavior of non-oscillatory solutions to forced-perturbed fractional differential equations with the Caputo fractional derivative.
Said R. Grace, Gokula N. Chhatria, S. Kaleeswari, Yousef Alnafisah, Osama Moaaz   +4 more
doaj   +1 more source

Pedagogical conservatism of university teachers [PDF]

Известия Саратовского университета. Новая серия: Акмеология образования. Психология развития
The relevance of the research is due to the need to implement the principle of cooperation and interaction of the subjects of the educational process, and to use the creative approach in the situation of modernizing higher education.
Avakyan, Inna B.
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Generalized Lagrangian symmetries depending on higher order derivatives. Conservation laws and the characteristic equation [PDF]

, 2003
G. Giachetta, L. Mangiarotti, G. Sardanashvily   +2 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of Higher Order Thinking Skills in English Lesson Plans

, 2021
Made Diana Ayu Hemas, Nyoman Karina Wedhanti, Putu Adi Krisna Juniarta   +2 more
openalex   +2 more sources