Results 181 to 190 of about 4,290,191 (312)

Evidence of Exposure to Highly Pathogenic Avian Influenza H5 Viruses in East Greenland Polar Bears. [PDF]

Emerg Infect Dis
Buhler KJ, Ranadheera C, Bastien N, Zirino M, Jenkins E, Tryland M, Dietz R, Søndergaard J, Sonne C.   +8 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Commentary on "Broadly Protective Antibody-Like Vaccines Against Highly Pathogenic Coronaviruses". [PDF]

J Med Virol
Mumtaz S.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Detection of Divergent Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Virus, São Paulo, Brazil, 2025. [PDF]

Emerg Infect Dis
de Araujo J, Thomazelli LM, Fabrizio TP, Fenner GO, Dorlass EG, Eisen AKA, Botosso VF, Nardi MS, Aires CC, Teixeira SMN, de Azevedo RM, Frediani MH, Ometto T, Barboza MGL, de Souza EE, Wrenger C, Webby RJ, Durigon EL.   +17 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Highly pathogenic avian influenza A (H5N1) in a backyard flock in Serbia: implications of low biosecurity. [PDF]

Front Public Health
Maletić J, Graziosi G, Maksimović Zorić J, Zdravković N, Aksić Đ, Jezimirović N, Kureljušić J, Nešić K, De Nardi M, Kureljušić B.   +9 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Molecular Characterization of Highly Pathogenic Marek's Disease Virus Strain in Vaccinated Iraqi Pullets. [PDF]

Adv Virol
Manswr BM, Hamad MA, Ali AEH, Jameel FR.
europepmc   +1 more source