Results 101 to 110 of about 3,804,425 (149)

Dual Antiviral and Immunomodulatory Effects of Phytochemicals in Influenza A Virus Infection: Targeting Key Host Signaling Pathways

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Influenza A virus modulates host innate immune pathways, including TLR, RIG‐I, MAPK, and NF‐κB signaling, to support replication and drive inflammatory pathology. Plant‐derived phytocompounds target these interconnected pathways, offering a potential host‐directed immunomodulatory approach complementary to conventional antivirals.
Dibakar Chowdhury, Hillary A. Vanderven, Phurpa Wangchuk, Subir Sarker   +3 more
wiley   +1 more source

A VSV-vector vaccine simultaneously targeting H5N1 hemagglutinin and matrix protein 2 induces robust neutralizing and ADCC antibody responses and provides full protection against lethal H5N1 infection in a mouse model

Journal of Virology
Avian influenza A viruses, especially highly pathogenic avian influenza (HPAI) viruses, pose a significant public health threat, and a multivalent vaccine is the primary prophylactic measure to control these viruses.
Zhujun Ao, Robert Vendramelli, Maryann Buyu, Thang Truong, Dayu Liu, Nick Gao, Heqing Ma, Stephen Amos, Peter Lawrynuik, Maurice Nyamekye, Keith R. Fowke, Peter Pelka, Maya Shmulevitz, Sam K. P. Kung, Darwyn Kobasa, Xiaojian Yao   +15 more
doaj   +1 more source

Multitechnique Physicochemical Characterization of Horse Hoof Trimmings as Sustainable and Untapped Keratin Source

ChemistryOpen, Volume 15, Issue 10, October 2026.
Horse hoof trimmings, cruelty‐free and traceable keratin‐rich waste, were characterized for particle size, morphology, thermal stability, composition and metal contamination. Results show a high higher‐heating value and promising upcycling paths for energy and materials, but variable metal contamination (shoeing‐ and milling‐dependent) requires ...
Esther Trigueros, Lisa Rita Magnaghi, Lorenzo De Vita, Lavinia Rita Doveri, Michela Sturini, Chiara Milanese, Raffaela Biesuz   +6 more
wiley   +1 more source

The consequences of host heterogeneity for parasite transmission depend on how host infectiousness is determined

Journal of Animal Ecology, Volume 95, Issue 10, Page 2063-2075, October 2026.
This study proposes two contrasting scenarios for how host infectiousness is determined: recipient dependence and donor dependence. These scenarios fundamentally alter how host heterogeneity shapes parasite transmission, demonstrating that the process by which infectiousness is determined is crucial for understanding the consequences of host ...
Jacob A. Cohen, Andrew D. Dean, Mark Viney, Andy Fenton   +3 more
wiley   +1 more source

Concurrent Acquisition of a Single Nucleotide Polymorphism in Diverse Influenza H5N1 Clade 2.2 Sub-clades [PDF]

, 2008
Highly pathogenic Influenza A H5N1 was first identified in Guangdong Province in 1996, followed by human cases in Hong Kong in 1997 1,2. The number of confirmed human cases now exceeds 300 and the associated Case Fatality Rate exceeds 60% 3.
Hala M. Esmat, Henry Niman, Mona M. Aly, William K. Ampofo, Nasr El-Sayed, Bruce R. Boynton, Abdel-Satar Arafa, Gregory A. Raczniak, Ahmed S. Abdelghani, Ahmed E. Nayel, Mensah Agyen-Frempong   +10 more
core  

Estimating the total mortality of seabirds following a marine heat wave

Conservation Biology, Volume 40, Issue 5, October 2026.
Abstract Marine heat waves detrimentally affect a range of marine species, including seabirds, and are increasing in frequency and severity. When thousands of dead seabirds wash up on beaches, the public becomes concerned. However, the number of dead birds recorded on beaches is only a fraction of the total mortality; most birds perish at sea.
Jennifer L. Lavers, William Fulton, Silke Stuckenbrock, Alexander L. Bond   +3 more
wiley   +1 more source

CLIMATE CHANGE INFLUENCES ON THE RISK OF AVIAN INFLUENZA OUTBREAKS AND ASSOCIATED ECONOMIC LOSS [PDF]

This paper examines the effect that climate has on Avian Influenza outbreak probability. The statistical analysis shows across a broad region the probability of an outbreak declines by 0.22% when the temperature rises 1 Celsius degree and increases by 0 ...
Mu, Jianhong H., McCarl, Bruce A., Wu, Ximing, Gan, Li   +3 more
core  

Incursion of Novel Eurasian Low Pathogenicity Avian Influenza H5 Virus, Australia, 2023

Emerging Infectious Diseases
Australia is a sink for low pathogenicity avian influenza viruses, with isolated circulation occurring on the continent. We report the incursion of a Eurasian low pathogenicity avian influenza H5 virus into Australia.
Michelle Wille, Victoria Grillo, Silvia Ban de Gouvea Pedroso, Natasha D. Brohier, Ivano Broz, Charlotte Burgoyne, Allison Crawley, Kelly Davies, Mark Ford, Joanne Grimsey, Nina Y.H. Kung, Jasmina M. Luczo, Cornelius Matereke, Peter T. Mee, Patrick Mileto, Matthew J. Neave, Megan Poon, Vittoria Stevens, Guy Weerasinghe, Sara Zufan, Ian G. Barr, Marcel Klaassen, Andrew C. Breed, Frank Y.K. Wong   +23 more
doaj   +1 more source

Inactivated H5 antigens of H5N8 protect chickens from lethal infections by the highly pathogenic H5N8 and H5N6 avian influenza viruses

Journal of Veterinary Research, 2018
Introduction: Highly pathogenic Asian H5-subtype avian influenza viruses have been found in poultry and wild birds worldwide since they were first detected in southern China in 1996. Extensive control efforts have not eradicated them.
Jin Myongha, Jang Yunyueng, Seo Taehyun, Seo Sang Heui   +3 more
doaj   +1 more source

Nomenclature Updates to the Hemagglutinin Gene Clade Designations Resulting From the Continued Evolution of High Pathogenicity Avian Influenza A(H5) Virus Clades 2.3.2.1c and 2.3.4.4

Influenza and Other Respiratory Viruses, Volume 20, Issue 10, October 2026.
ABSTRACT Background and Methods The evolutionary divergence of the A(H5) hemagglutinin (HA) gene of high pathogenicity avian influenza (HPAI) viruses (A/goose/Guangdong/96 lineage) was analyzed by phylogenetic and average pairwise distance methods to identify clades that merit nomenclature updates.
Tommy T. Lam, C. Todd Davis, World Health Organization/World Organisation for Animal Health/Food and Agriculture Organization (WHO/WOAH/FAO) H5 Evolution Working Group, Francesco Bonfante, Ian H. Brown, Lorcan Carnegie, Amelia Coggon, C. Todd Davis, Alice Fusaro, Ron A. M. Fouchier, Yi Guan, Hideki Hasegawa, Yunho Jang, Erik A. Karlsson, Mia Kim‐Torchetti, Tommy Lam, Nicola S. Lewis, Isabella Monne, Gounalan Pavade, Magdi Samaan, Samuel S. Shepard, David Suarez, Dayan Wang, Richard Webby, Frank Wong, Wenqing Zhang   +25 more
wiley   +1 more source