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HILIC-UPLC-MS for Exploratory Urinary Metabolic Profiling in Toxicological Studies
Analytical Chemistry, 2010Hydrophilic interaction ultra performance liquid chromatography (HILIC-UPLC) permits the analysis of highly polar metabolites, providing complementary information to reversed-phase (RP) chromatography. HILIC-UPLC-TOF-MS was investigated for the global metabolic profiling of rat urine samples generated in an experimental hepatotoxicity study of ...
Konstantina, Spagou +10 more
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HILIC-UPLC Analysis of Brain Tissue N-Glycans
2016Extraction of N-glycans from intact tissue presents a unique set of challenges which makes it a relatively laborious and time-consuming process in comparison to other sample types, such as plasma. Here we present an approach designed for the extraction, purification, and labeling of free N-glycans from brain tissue.
Gudelj, Ivan, Klarić, Thomas
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Analytical and Bioanalytical Chemistry, 2010
A hydrophilic interaction chromatography-based method, in combination with 1.7 microm ethylene bridged hybrid particle packed column (100 mm x 2.1 mm I.D.) and ultraperformance liquid chromatography, has been developed to measure cytosine (C) and methylcytosine (mC) in order to evaluate the extent of DNA methylation.
Sotgia S +7 more
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A hydrophilic interaction chromatography-based method, in combination with 1.7 microm ethylene bridged hybrid particle packed column (100 mm x 2.1 mm I.D.) and ultraperformance liquid chromatography, has been developed to measure cytosine (C) and methylcytosine (mC) in order to evaluate the extent of DNA methylation.
Sotgia S +7 more
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HILIC-UPLC-MS N-GLYCAN CHARACTERIZATION IN THE DIAGNOSIS OF CONGENITAL DISORDERS OF GLYCOSYLATION
2020Congenital Disorders of Glycosylation (CDG) are genetic diseases characterized by altered glycosylation of proteins, lipids and/or both. To discover disease-associated biomarkers, as well as to identify changing in N-glycomic profiles supporting diagnosis of congenital disorders of glycosylation, was applied a High Throughput (HT) method based on ...
Angela Messina +5 more
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Drug Testing and Analysis, 2014
Ginkgo biloba leaf extract has been widely used in dietary supplements and more recently in some foods and beverages. In addition to the well‐known flavonol glycosides and terpene lactones, G. biloba leaves are also rich in nucleobases and nucleosides. To determine the content of nucleobases and nucleosides in G.
Xin, Yao +5 more
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Ginkgo biloba leaf extract has been widely used in dietary supplements and more recently in some foods and beverages. In addition to the well‐known flavonol glycosides and terpene lactones, G. biloba leaves are also rich in nucleobases and nucleosides. To determine the content of nucleobases and nucleosides in G.
Xin, Yao +5 more
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Biomedical Chromatography, 2017
AbstractGuizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrhea (PD). However, the intervention effective mechanism in vivo has not been well elucidated.
Lang Lang +5 more
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AbstractGuizhi Fuling capsule (GFC), developed from the traditional Chinese prescription of Guizhi Fuling Wan, has been commonly used for the treatment of primary dysmenorrhea (PD). However, the intervention effective mechanism in vivo has not been well elucidated.
Lang Lang +5 more
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Rapid Communications in Mass Spectrometry
ABSTRACT Rationale Accurate quantification of neurotransmitters and hormones within the hypothalamic–pituitary–adrenal (HPA) axis is essential for elucidating their pathological roles in neurodegenerative diseases. Methods
Jiale Li +10 more
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ABSTRACT Rationale Accurate quantification of neurotransmitters and hormones within the hypothalamic–pituitary–adrenal (HPA) axis is essential for elucidating their pathological roles in neurodegenerative diseases. Methods
Jiale Li +10 more
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2017
Rising awareness of universal importance of protein N-glycosylation governs the development and further advances in N-glycan analysis. Nowadays it’s well known that correct glycosylation is essential for proper protein function, which emanates with its important role in many physiological processes and pathophysiology of multiple common complex ...
Gornik Kljaić, Olga +3 more
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Rising awareness of universal importance of protein N-glycosylation governs the development and further advances in N-glycan analysis. Nowadays it’s well known that correct glycosylation is essential for proper protein function, which emanates with its important role in many physiological processes and pathophysiology of multiple common complex ...
Gornik Kljaić, Olga +3 more
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2016
Neonatal sepsis is a severe infection which is caused by microorganisms in the blood of neonates and, it is associated with increased morbidity and mortality. Early, rapid and accurate diagnosis of neonatal sepsis is a major challenge in neonatology and, hence, the discovery of biomarkers of high diagnostic accuracy is particularly important ...
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Neonatal sepsis is a severe infection which is caused by microorganisms in the blood of neonates and, it is associated with increased morbidity and mortality. Early, rapid and accurate diagnosis of neonatal sepsis is a major challenge in neonatology and, hence, the discovery of biomarkers of high diagnostic accuracy is particularly important ...
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