Results 1 to 10 of about 13,626,059 (252)
Recent Advances in the Chemical Biology of N-Glycans
Molecules, 2021 Asparagine-linked N-glycans on proteins have diverse structures, and their functions vary according to their structures. In recent years, it has become possible to obtain high quantities of N-glycans via isolation and chemical/enzymatic/chemoenzymatic ...
Asuka Shirakawa +2 more
doaj +2 more sources
Lack of complex type N-glycans lessens aberrant neuronal properties. [PDF]
PLoS ONE, 2018 Modifications in surface glycans attached to proteins via N-acetylglucosamine-β1-N-asparagine linkage have been linked to tumor development and progression.
M Kristen Hall +3 more
doaj +2 more sources
Unveiling the Sugary Secrets of Plasmodium Parasites
Frontiers in Microbiology, 2021 Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year.
Felix Goerdeler +4 more
doaj +1 more source
Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies
Scientific Reports, 2022 The Madin-Darby canine kidney (MDCK) cell line is an in vitro model for influenza A virus (IAV) infection and propagation. MDCK-SIAT1 (SIAT1) and humanized MDCK (hCK) cell lines are engineered MDCK cells that express N-glycans with elevated levels of ...
Lauren Byrd-Leotis +6 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 Glycosylation, the process of adding glycans (i.e., sugars) to proteins, is the most abundant post-translational modification. N-glycosylation is the most common form of glycosylation, and the N-glycan moieties play key roles in regulating protein ...
Lei Yu +12 more
doaj +1 more source
Site-Specific Profiling of N-Glycans in Drosophila melanogaster
Frontiers in Bioscience-Landmark, 2023 Background: Drosophila melanogaster is a well-studied and highly tractable genetic model system for deciphering the molecular mechanisms underlying various biological processes.
Fei Zhao +6 more
doaj +1 more source
Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities. [PDF]
PLoS ONE, 2015 Many therapeutic antibodies have been developed, and IgG antibodies have been extensively generated in various cell expression systems. IgG antibodies contain N-glycans at the constant region of the heavy chain (Fc domain), and their N-glycosylation ...
Masaki Kurogochi +14 more
doaj +1 more source
Frontiers in Immunology, 2020 Toll-like receptor 8 (TLR-8) plays a role in the pathogenesis of autoimmune disorders and associated gastrointestinal symptoms that reduce quality of life of patients. Dietary interventions are becoming more accepted as mean to manage onset, progression,
Susana Figueroa-Lozano +6 more
doaj +1 more source
N-glycans: phenotypic homology and structural differences between myocardial cells and induced pluripotent stem cell-derived cardiomyocytes. [PDF]
PLoS ONE, 2014 Cell surface glycans vary widely, depending on cell properties. We hypothesized that glycan expression on induced pluripotent stem cells (iPSCs) might change during cardiomyogenic differentiation toward the myocardial phenotype.
Takuji Kawamura +13 more
doaj +1 more source
PLoS ONE, 2015 The HIV envelope glycoprotein gp120 contains nine disulphide bridges and is highly glycosylated, carrying on average 24 N-linked glycans. Using a probability calculation, we here demonstrate that there is a co-localization of disulphide bridges and N ...
Leen Mathys, Jan Balzarini
doaj +1 more source