Recent Advances in the Chemical Biology of N-Glycans
Molecules, 2021 Asparagine-linked N-glycans on proteins have diverse structures, and their functions vary according to their structures. In recent years, it has become possible to obtain high quantities of N-glycans via isolation and chemical/enzymatic/chemoenzymatic ...
Asuka Shirakawa +2 more
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Lack of complex type N-glycans lessens aberrant neuronal properties. [PDF]
PLoS ONE, 2018 Modifications in surface glycans attached to proteins via N-acetylglucosamine-β1-N-asparagine linkage have been linked to tumor development and progression.
M Kristen Hall +3 more
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PLoS ONE, 2020 ObjectivesIslet transplantation is an emerging treatment option for type 1 diabetes but its application is limited by the shortage of human pancreas donors.
Yoshihide Nanno +5 more
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Unveiling the Sugary Secrets of Plasmodium Parasites
Frontiers in Microbiology, 2021 Plasmodium parasites cause malaria disease, one of the leading global health burdens for humanity, infecting hundreds of millions of people each year.
Felix Goerdeler +4 more
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Sialylated and sulfated N-Glycans in MDCK and engineered MDCK cells for influenza virus studies
Scientific Reports, 2022 The Madin-Darby canine kidney (MDCK) cell line is an in vitro model for influenza A virus (IAV) infection and propagation. MDCK-SIAT1 (SIAT1) and humanized MDCK (hCK) cell lines are engineered MDCK cells that express N-glycans with elevated levels of ...
Lauren Byrd-Leotis +6 more
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Frontiers in Aging Neuroscience, 2021 Glycosylation, the process of adding glycans (i.e., sugars) to proteins, is the most abundant post-translational modification. N-glycosylation is the most common form of glycosylation, and the N-glycan moieties play key roles in regulating protein ...
Lei Yu +12 more
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N-Glycans in cancer progression [PDF]
Glycobiology, 2008 N-Glycan branching in the medial-Golgi generates ligands for lattice-forming lectins (e.g., galectins) that regulate surface levels of glycoproteins including epidermal growth factor (EGF) and transforming growth factor-beta (TGF-beta) receptors. Moreover, functional classes of glycoproteins differ in N-glycan multiplicities (number of N-glycans ...
Ken S, Lau, James W, Dennis
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Site-Specific Profiling of N-Glycans in Drosophila melanogaster
Frontiers in Bioscience-Landmark, 2023 Background: Drosophila melanogaster is a well-studied and highly tractable genetic model system for deciphering the molecular mechanisms underlying various biological processes.
Fei Zhao +6 more
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Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcγRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities. [PDF]
PLoS ONE, 2015 Many therapeutic antibodies have been developed, and IgG antibodies have been extensively generated in various cell expression systems. IgG antibodies contain N-glycans at the constant region of the heavy chain (Fc domain), and their N-glycosylation ...
Masaki Kurogochi +14 more
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N-glycans: phenotypic homology and structural differences between myocardial cells and induced pluripotent stem cell-derived cardiomyocytes. [PDF]
PLoS ONE, 2014 Cell surface glycans vary widely, depending on cell properties. We hypothesized that glycan expression on induced pluripotent stem cells (iPSCs) might change during cardiomyogenic differentiation toward the myocardial phenotype.
Takuji Kawamura +13 more
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