Results 21 to 30 of about 13,626,059 (252)

Characterization of recombinant human lactoferrin N-glycans expressed in the milk of transgenic cows.

PLoS ONE, 2017
Lactoferrin (LF) is one of the most abundant bioactive glycoproteins in human milk. Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities. In contrast, LF is present in trace amounts in bovine milk.
Annabelle Le Parc, Sercan Karav, Camille Rouquié, Elizabeth A Maga, Apichaya Bunyatratchata, Daniela Barile   +5 more
doaj   +1 more source

Change in N-Glycosylation of Plasma Proteins in Japanese Semisupercentenarians. [PDF]

PLoS ONE, 2015
An N-glycomic analysis of plasma proteins was performed in Japanese semisupercentenarians (SSCs) (mean 106.7 years), aged controls (mean 71.6 years), and young controls (mean 30.2 years) by liquid chromatography/mass spectrometry (LC/MS) using a ...
Yuri Miura, Noritaka Hashii, Hiroki Tsumoto, Daisuke Takakura, Yuki Ohta, Yukiko Abe, Yasumichi Arai, Nana Kawasaki, Nobuyoshi Hirose, Tamao Endo, SONIC (Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians)   +10 more
doaj   +1 more source

Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds [PDF]

, 2010
ER resident glycoproteins, including ectopically expressed recombinant glycoproteins, carry so-called high-mannose type N-glycans, which can be at different stages of processing.
Maurice Henquet, Alexander van der Krol, Mariëlle Schreuder, Schreuder, M., Dirk Bosch, Cordewener, J., Schreuder, M.E.L., Depicker, A., Eigenhuijsen, Jochem, Jan Cordewener, Hesselink, T., Depicker, Anna, Bosch, D., Ann Depicker, Henquet, M.G.L., Spiegel, Holger, Henquet, M., Thamara Hesselink, Spiegel, H., Depicker, AnnaWE098010003776500000-0003-0105-7407F3E47A04-F0ED-11E1-A9DE-61C894A0A6B4, Henquet, Maurice, Jochem Eigenhuijsen, Cordewener, J.H.G., Schreuder, Mariëlle, van der Krol, Alexander, Bosch, H.J., Duijn, E., van, van Duijn, E., Krol, A.R., van der, Hesselink, Thamara, van Duijn, Esther, Cordewener, Jan, Eigenhuijsen, J., Bosch, Dirk, Esther van Duijn, Holger Spiegel, van der Krol, A.R.   +36 more
core   +1 more source

Structural feature of N-glycans of bamboo shoot glycoproteins: useful source of plant antigenic N-glycans [PDF]

, 2017
An effective method to prepare plant complex type (PCT) N-glycans in large amounts has been required to evaluate their immunological activity. In this study, we found that glycoproteins in bamboo shoots predominantly carry PCT N-glycans including the ...
Megumi, Maeda, Yoshinobu, Kimura, Kaori, Furuta, Tanabe, Chinatsu   +3 more
core   +3 more sources

Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Frontiers in Immunology, 2018
Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.
Fleur S. van de Bovenkamp, Fleur S. van de Bovenkamp, Ninotska I. L. Derksen, Ninotska I. L. Derksen, Mariëlle J. van Breemen, Steven W. de Taeye, Steven W. de Taeye, Steven W. de Taeye, Pleuni Ooijevaar-de Heer, Pleuni Ooijevaar-de Heer, Rogier W. Sanders, Rogier W. Sanders, Theo Rispens, Theo Rispens   +13 more
doaj   +1 more source

Serum Protein N-Glycosylation Signatures of Neuroblastoma

Frontiers in Oncology, 2021
BackgroundNeuroblastoma is the most common extracranial childhood solid tumor which accounts for 10% of the malignancies and 15% of the cancer fatalities in children.
Wenjun Qin, Hao Pei, Xiaobing Li, Jia Li, Xuelian Yao, Rufang Zhang   +5 more
doaj   +1 more source

Towards Mapping of the Human Brain N-Glycome with Standardized Graphitic Carbon Chromatography

Biomolecules, 2022
The brain N-glycome is known to be crucial for many biological functions, including its involvement in neuronal diseases. Although large structural studies of brain N-glycans were recently carried out, a comprehensive isomer-specific structural analysis ...
Johannes Helm, Lena Hirtler, Friedrich Altmann   +2 more
doaj   +1 more source

Correlation of N-glycan dynamics and interaction network with allosteric antigen binding and Fc receptor recognition

Exploration of Immunology, 2021
Aim: Fragment crystallizable (Fc) glycans modulate Fc conformations and functions, and glycan may also regulate antigen recognition. In the antibody drug development, glycosylation patterns affect antibody drug characteristics and quality control.
Buyong Ma
doaj   +1 more source

N-glycans released from glycoproteins using a commercial kit and comprehensively analyzed with a hypothetical database

Journal of Pharmaceutical Analysis, 2017
The glycosylation of proteins is responsible for their structural and functional roles in many cellular activities. This work describes a strategy that combines an efficient release, labeling and liquid chromatography-mass spectral analysis with the use ...
Xue Sun, Lei Tao, Lin Yi, Yilan Ouyang, Naiyu Xu, Duxin Li, Robert J. Linhardt, Zhenqing Zhang   +7 more
doaj   +1 more source

Co-Expression of NEU2 and GBA3 Causes a Drastic Reduction in Cytosolic Sialyl Free N-glycans in Human MKN45 Stomach Cancer Cells—Evidence for the Physical Interaction of NEU2 and GBA3

Biomolecules, 2015
It is well known that the “free” form of glycans that are structurally related to asparagine (N)-linked glycans (“free N-glycans”) are found in a wide variety of organisms.
Li Wang, Junichi Seino, Haruna Tomotake, Yoko Funakoshi, Hiroto Hirayama, Tadashi Suzuki   +5 more
doaj   +1 more source